Emerging importance of ACE2 in external stratified epithelial tissues.
Mol Cell Endocrinol
; 529: 111260, 2021 06 01.
Article
in English
| MEDLINE | ID: covidwho-1157602
ABSTRACT
Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system (RAS), has been identified as the receptor for the SARS-CoV-2. Several RAS components including ACE2 and its substrate Ang II are present in both eye and skin, two stratified squamous epithelial tissues that isolate organisms from external environment. Our recent findings in cornea and others in both skin and eye suggest contribution of this system, and specifically of ACE2 in variety of physiological and pathological responses of these organ systems. This review will focus on the role RAS system plays in both skin and cornea, and will specifically discuss our recent findings on ACE2 in corneal epithelial inflammation, as well as potential implications of ACE2 in patients with COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Skin
/
Epithelium, Corneal
/
Receptors, Coronavirus
/
Angiotensin-Converting Enzyme 2
Limits:
Humans
Language:
English
Journal:
Mol Cell Endocrinol
Year:
2021
Document Type:
Article
Affiliation country:
J.mce.2021.111260
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