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Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin.
Sehirli, Ahmet Özer; Aksoy, Umut; Koca-Ünsal, Revan Birke; Sayiner, Serkan.
  • Sehirli AÖ; Department of Pharmacology, Faculty of Dentistry, Near East University, Nicosia 99138, Cyprus.
  • Aksoy U; Department of Endodontics, Faculty of Dentistry, Near East University, Nicosia 99138, Cyprus.
  • Koca-Ünsal RB; Department of Periodontology, Faculty of Dentistry, University of Kyrenia, Kyrenia 99320, Cyprus. Electronic address: revanbirke.koca@kyrenia.edu.tr.
  • Sayiner S; Department of Biochemistry, Faculty of Veterinary Medicine, Near East University, Nicosia 99138, Cyprus; Animal Hospital, Diagnostic Laboratory, Faculty of Veterinary Medicine, Near East University, Nicosia 99138, Cyprus.
Med Hypotheses ; 151: 110588, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1157615
ABSTRACT
Daily new information emerges regarding the COVID-19, infection of SARS-CoV-2, which is considered a global pandemic. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are required to complete the viral invasion pathway and are present in the oral mucosa, gingiva and periodontal pocket. Thus, increasing the likelihood of periodontitis and gingivitis caused by COVID-19. The cytokine storm during COVID-19 similarly arises during periodontal inflammation. Studies have reported that NOD-Like Receptor family pyrin domain-containing 3 (NLRP3) inflammasome is significant in the cytokine storm. Recently, the course of the COVID-19 has been related to the melatonin levels in both COVID-19 and periodontal diseases. It is known that melatonin prevents the activation of NLRP3 inflammasome. In light of these findings, we think that melatonin treatment during COVID-19 or periodontal diseases may prevent the damage seen in periodontal tissues by preventing the activation of NLRP3 inflammasome.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Periodontitis / COVID-19 / Melatonin Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Med Hypotheses Year: 2021 Document Type: Article Affiliation country: J.mehy.2021.110588

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Periodontitis / COVID-19 / Melatonin Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Med Hypotheses Year: 2021 Document Type: Article Affiliation country: J.mehy.2021.110588