Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin.
Med Hypotheses
; 151: 110588, 2021 Jun.
Article
in English
| MEDLINE | ID: covidwho-1157615
ABSTRACT
Daily new information emerges regarding the COVID-19, infection of SARS-CoV-2, which is considered a global pandemic. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are required to complete the viral invasion pathway and are present in the oral mucosa, gingiva and periodontal pocket. Thus, increasing the likelihood of periodontitis and gingivitis caused by COVID-19. The cytokine storm during COVID-19 similarly arises during periodontal inflammation. Studies have reported that NOD-Like Receptor family pyrin domain-containing 3 (NLRP3) inflammasome is significant in the cytokine storm. Recently, the course of the COVID-19 has been related to the melatonin levels in both COVID-19 and periodontal diseases. It is known that melatonin prevents the activation of NLRP3 inflammasome. In light of these findings, we think that melatonin treatment during COVID-19 or periodontal diseases may prevent the damage seen in periodontal tissues by preventing the activation of NLRP3 inflammasome.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Periodontitis
/
COVID-19
/
Melatonin
Type of study:
Experimental Studies
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Med Hypotheses
Year:
2021
Document Type:
Article
Affiliation country:
J.mehy.2021.110588
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