Your browser doesn't support javascript.
Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development.
Lionetti, Vincenzo; Bollini, Sveva; Coppini, Raffaele; Gerbino, Andrea; Ghigo, Alessandra; Iaccarino, Guido; Madonna, Rosalinda; Mangiacapra, Fabio; Miragoli, Michele; Moccia, Francesco; Munaron, Luca; Pagliaro, Pasquale; Parenti, Astrid; Pasqua, Teresa; Penna, Claudia; Quaini, Federico; Rocca, Carmine; Samaja, Michele; Sartiani, Laura; Soda, Teresa; Tocchetti, Carlo Gabriele; Angelone, Tommaso.
  • Lionetti V; Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy; UOSVD Anesthesia and Intensive Care, Fondazione Toscana G. Monasterio, Pisa, Italy. Electronic address: v.lionetti@santannapisa.it.
  • Bollini S; Regenerative Medicine Laboratory, Department of Experimental Medicine, University of Genova, Genova, Italy.
  • Coppini R; Department of NEUROFARBA, Center of Molecular Medicine, University of Firenze, 50139 Firenze, Italy.
  • Gerbino A; Department of Bioscience, Biotechnology and Biopharmaceuticals, University of Bari, Bari, Italy.
  • Ghigo A; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.
  • Iaccarino G; Department of Advanced Biomedical Sciences, Federico II University, Italy.
  • Madonna R; Institute of Cardiology, University of Pisa, Pisa, Italy; Center for Cardiovascular Biology and Atherosclerosis Research, McGovern School of Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Mangiacapra F; Unit of Cardiovascular Science, Campus Bio-Medico University, Rome, Italy.
  • Miragoli M; Department of Medicine and Surgery, University of Parma, Parma, Italy.
  • Moccia F; Department of Biology and Biotechnology, Laboratory of General Physiology, University of Pavia, Pavia, Italy. Electronic address: francesco.moccia@unipv.it.
  • Munaron L; Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy.
  • Pagliaro P; Clinical and Biological Sciences Department, University of Turin, Orbassano, Turin, Italy.
  • Parenti A; Department of Health Sciences, University of Florence, Florence, Italy.
  • Pasqua T; Department of Health Science, University of Magna Graecia, Catanzaro, Italy.
  • Penna C; Clinical and Biological Sciences Department, University of Turin, Orbassano, Turin, Italy.
  • Quaini F; Department of Medicine and Surgery, Hematology and Bone Marrow Transplantation, University Hospital of Parma, Via Gramsci 14, 43126 Parma, Italy.
  • Rocca C; Laboratory of Cellular and Molecular Cardiovascular Patho-Physiology, Department of Biology, E. and E.S., University of Calabria, Arcavacata di Rende, CS, Italy.
  • Samaja M; Department of Health Science, University of Milano, Milan, Italy.
  • Sartiani L; Department of NEUROFARBA, Center of Molecular Medicine, University of Firenze, 50139 Firenze, Italy.
  • Soda T; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
  • Tocchetti CG; Interdepartmental Center of Clinical and Translational Research, Federico II University, Naples, Italy.
  • Angelone T; Laboratory of Cellular and Molecular Cardiovascular Patho-Physiology, Department of Biology, E. and E.S., University of Calabria, Arcavacata di Rende, CS, Italy.
Pharmacol Res ; 168: 105581, 2021 06.
Article in English | MEDLINE | ID: covidwho-1157664
ABSTRACT
In-depth characterization of heart-brain communication in critically ill patients with severe acute respiratory failure is attracting significant interest in the COronaVIrus Disease 19 (COVID-19) pandemic era during intensive care unit (ICU) stay and after ICU or hospital discharge. Emerging research has provided new insights into pathogenic role of the deregulation of the heart-brain axis (HBA), a bidirectional flow of information, in leading to severe multiorgan disease syndrome (MODS) in patients with confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Noteworthy, HBA dysfunction may worsen the outcome of the COVID-19 patients. In this review, we discuss the critical role HBA plays in both promoting and limiting MODS in COVID-19. We also highlight the role of HBA as new target for novel therapeutic strategies in COVID-19 in order to open new translational frontiers of care. This is a translational perspective from the Italian Society of Cardiovascular Researches.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Brain Diseases / COVID-19 / Heart / Heart Diseases Type of study: Prognostic study Topics: Traditional medicine Limits: Humans Language: English Journal: Pharmacol Res Journal subject: Pharmacology Year: 2021 Document Type: Article

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Brain Diseases / COVID-19 / Heart / Heart Diseases Type of study: Prognostic study Topics: Traditional medicine Limits: Humans Language: English Journal: Pharmacol Res Journal subject: Pharmacology Year: 2021 Document Type: Article