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Endothelial-Mesenchymal Transition in COVID-19 lung lesions.
Falleni, Monica; Tosi, Delfina; Savi, Federica; Chiumello, Davide; Bulfamante, Gaetano.
  • Falleni M; Unità di Anatomia Patologica, Dipartimento di Scienze della Salute, Università degli Studi di Milano, 20142, Milan, Italy; Struttura Complessa Dipartimentale di Anatomia Patologica e Genetica Medica, ASST Santi Paolo e Carlo, 20142, Milan, Italy. Electronic address: monica.falleni@unimi.it.
  • Tosi D; Unità di Anatomia Patologica, Dipartimento di Scienze della Salute, Università degli Studi di Milano, 20142, Milan, Italy.
  • Savi F; Struttura Complessa Dipartimentale di Anatomia Patologica e Genetica Medica, ASST Santi Paolo e Carlo, 20142, Milan, Italy.
  • Chiumello D; Anestesia e Rianimazione, Ospedale, Centro ricerca coordinata di insufficienza respiratoria, Dipartimento di Scienze della Salute, Università degli Studi di Milano ASST Santi Paolo e Carlo, 20142, Milan, Italy.
  • Bulfamante G; Unità di Anatomia Patologica, Dipartimento di Scienze della Salute, Università degli Studi di Milano, 20142, Milan, Italy; Struttura Complessa Dipartimentale di Anatomia Patologica e Genetica Medica, ASST Santi Paolo e Carlo, 20142, Milan, Italy.
Pathol Res Pract ; 221: 153419, 2021 May.
Article in English | MEDLINE | ID: covidwho-1157674
ABSTRACT
Sars-Cov-2 infection is still a healthcare emergency and acute respiratory distress failure with Diffuse Alveolar Damage (DAD) features is the main causes of patients' death. Pathogenic mechanisms of the disease are not clear yet, but new insights are necessary to improve therapeutic management, to prevent fatal irreversible multi-organ damage and to adequately follow up those patients who survive. Here we investigated, by histochemistry and immunohistochemistry, a wide number of mapped lung specimens taken from whole body autopsies of 7 patients dead of COVID-19 disease. Our data confirm morphological data of other authors, and enlarge recent reports of the literature suggesting that Endothelial-Mesenchymal Transition might be central to COVID-19 lung fibrosing lesions. Furthermore, based upon recent acquisition of new roles in immunity and vascular pathology of the CD31 molecule, we hypothesize that this molecule might be important in the development and treatment of COVID-19 pulmonary lesions. These preliminary findings need further investigations to shed light on the complexity of Sars-Cov-2 disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Epithelial-Mesenchymal Transition / COVID-19 / Lung Diseases Type of study: Cohort study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Pathol Res Pract Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Epithelial-Mesenchymal Transition / COVID-19 / Lung Diseases Type of study: Cohort study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Pathol Res Pract Year: 2021 Document Type: Article