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Pre-Procedural COVID-19 Nasopharyngeal Swab Has Good Concordance with Bronchoalveolar Lavage in Patients at Low Risk for Viral Infection.
Oberg, Catherine L; Ronaghi, Reza; Folch, Erik E; Channick, Colleen L; He, Tao; Susanto, Irawan; Oh, Scott S.
  • Oberg CL; Section of Interventional Pulmonology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Ronaghi R; Section of Interventional Pulmonology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Folch EE; Section of Interventional Pulmonology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Channick CL; Section of Interventional Pulmonology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • He T; Section of Interventional Pulmonology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Susanto I; Section of Interventional Pulmonology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Oh SS; Section of Interventional Pulmonology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Respiration ; 100(6): 510-514, 2021.
Article in English | MEDLINE | ID: covidwho-1158153
Semantic information from SemMedBD (by NLM)
1. Bronchoscopic irrigation USES Artificial Airways
Subject
Bronchoscopic irrigation
Predicate
USES
Object
Artificial Airways
2. Bronchoscopic procedure TREATS Patients
Subject
Bronchoscopic procedure
Predicate
TREATS
Object
Patients
3. Screening procedure DIAGNOSES Symptoms
Subject
Screening procedure
Predicate
DIAGNOSES
Object
Symptoms
4. Bronchoscopic irrigation USES Artificial Airways
Subject
Bronchoscopic irrigation
Predicate
USES
Object
Artificial Airways
5. Bronchoscopic procedure TREATS Patients
Subject
Bronchoscopic procedure
Predicate
TREATS
Object
Patients
6. Screening procedure DIAGNOSES Symptoms
Subject
Screening procedure
Predicate
DIAGNOSES
Object
Symptoms
ABSTRACT

BACKGROUND:

The coronavirus disease 2019 (COVID-19) pandemic has drastically affected hospital and operating room (OR) workflow around the world as well as trainee education. Many institutions have instituted mandatory preoperative SARS-CoV-2 PCR nasopharyngeal swab (NS) testing in patients who are low risk for COVID-19 prior to elective cases. This method, however, is challenging as the sensitivity, specificity, and overall reliability of testing remains unclear.

OBJECTIVES:

The objective of this study was to assess the concordance of a negative NS in low risk preoperative patients with lower airway bronchoalveolar lavage (BAL) specimens obtained from the same patients.

METHODS:

We prospectively sent intraoperative lower airway BAL samples collected within 48 h of a negative mandatory preoperative NS for SARS-CoV-2 PCR testing. All adult patients undergoing a scheduled bronchoscopic procedure for any reason were enrolled, including elective and nonelective cases.

RESULTS:

One-hundred eighty-nine patients were included. All BAL specimens were negative for SARS-CoV-2 indicative of 100% concordance between testing modalities.

CONCLUSIONS:

These results are promising and suggest that preoperative nasopharyngeal SARS-CoV-2 testing provides adequate screening to rule out active COVID-19 infection prior to OR cases in a population characterized as low risk by negative symptom screening. This information can be used for both pre-procedural screening and when reintroducing trainees into the workforce.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Bronchoalveolar Lavage Fluid / Carrier State / Nasopharynx / COVID-19 Nucleic Acid Testing / COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors / Screening study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Respiration Year: 2021 Document Type: Article Affiliation country: 000514928

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bronchoalveolar Lavage Fluid / Carrier State / Nasopharynx / COVID-19 Nucleic Acid Testing / COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors / Screening study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Respiration Year: 2021 Document Type: Article Affiliation country: 000514928