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Progress and perspective of potential anti-coronavirus activity of phenothiazines
Yaoxue Xuebao ; 55(11):2529-2534, 2020.
Article in Chinese | EMBASE | ID: covidwho-1158862
ABSTRACT
Coronaviruses (CoVs) are associated with some mammalian infectious diseases, which have caused several outbreaks of respiratory system infectious diseases in recent years. There is no effective vaccine or approved drug treatment against coronaviruses, and the development of anti-coronavirus agents is an urgent priority. Pheno-thiazines are a class of antipsychotic drugs, which were found that they have some other biological activities, like promising antibacterial, antifungal, anticancer, antiviral, etc. They can be used for drug repurposing. This review summarizes current researches on the potential anti-coronavirus activity of phenothiazine, discusses the mechanisms and some research difficulties, and provides a foundation for developing anti-coronavirus drugs which use phenothiazine as the lead compound.

Full text: Available Collection: Databases of international organizations Database: EMBASE Language: Chinese Journal: Yaoxue Xuebao Year: 2020 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: Chinese Journal: Yaoxue Xuebao Year: 2020 Document Type: Article