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COVID-19 and Thromboinflammation: Is There a Role for Statins?
Ferrari, Filipe; Martins, Vítor M; Teixeira, Marcelo; Santos, Raul D; Stein, Ricardo.
  • Ferrari F; Programa de Pos-Graduacao em Cardiologia e Ciencias Cardiovasculares, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BR.
  • Martins VM; Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, BR.
  • Teixeira M; Programa de Pos-Graduacao em Cardiologia e Ciencias Cardiovasculares, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BR.
  • Santos RD; Hospital Israelita Albert Einstein, Sao Paulo, SP, BR.
  • Stein R; Unidade Clinica de Lipides, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
Clinics (Sao Paulo) ; 76: e2518, 2021.
Article in English | MEDLINE | ID: covidwho-1159487
ABSTRACT
The novel coronavirus disease (COVID-19) showed increased morbidity and mortality rates and worse prognosis in individuals with underlying chronic diseases, especially cardiovascular disease and its risk factors, such as hypertension, diabetes, and obesity. There is also evidence of possible links among COVID-19, myocardial infarction, and stroke. Emerging evidence suggests a pro-inflammatory milieu and hypercoagulable state in patients with this infection. Despite anticoagulation, a large proportion of patients requiring intensive care may develop life-threatening thrombotic complications. Indeed, the levels of some markers of hemostatic activation, such as D-dimer, are commonly elevated in COVID-19, indicating potential risk of deep vein thrombosis and pulmonary thromboembolism. In this review, we critically examine and discuss aspects of hypercoagulability and inflammation in COVID-19 and the possible benefits of statins in this scenario, with emphasis on their underlying molecular mechanisms. Moreover, we present recommendations on the use of antiviral drugs in combination with statins.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Coronavirus / Hydroxymethylglutaryl-CoA Reductase Inhibitors / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Clinics (Sao Paulo) Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Clinics

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Coronavirus / Hydroxymethylglutaryl-CoA Reductase Inhibitors / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Clinics (Sao Paulo) Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Clinics