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Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?
Hassani, Danesh; Amiri, Mohammad Mehdi; Maghsood, Faezeh; Salimi, Vahid; Kardar, Gholam Ali; Barati, Omid; Hashemian, Seyed Mohammad Reza; Jeddi-Tehrani, Mahmood; Zarnani, Amir-Hassan; Shokri, Fazel.
  • Hassani D; Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Immunol ; 18(1): 47-53, 2021 03.
Article in English | MEDLINE | ID: covidwho-2091347
ABSTRACT

BACKGROUND:

Incidence and severity of SARS-CoV2 infection are significantly lower in children and teenagers proposing that certain vaccines, routinely administered to neonates and children may provide cross-protection against this emerging infection.

OBJECTIVE:

To assess the cross-protection induced by prior measles, mumps and rubella (MMR) vaccinations against COVID-19.

METHODS:

The antibody responses to MMR and tetanus vaccines were determined in 53 patients affected with SARS-CoV2 infection and 52 age-matched healthy subjects. Serum levels of antibodies specific for NP and RBD of SARS-CoV2 were also determined in both groups of subjects with ELISA.

RESULTS:

Our results revealed significant differences in anti-NP (P<0.0001) and anti-RBD (P<0.0001) IgG levels between patients and healthy controls. While the levels of rubella- and mumps specific IgG were not different in the two groups of subjects, measles-specific IgG was significantly higher in patients (P<0.01). The serum titer of anti-tetanus antibody, however, was significantly lower in patients compared to healthy individuals (P<0.01).

CONCLUSION:

Our findings suggest that measles vaccination triggers those B cells cross-reactive with SARS-CoV2 antigens leading to the production of increased levels of measles-specific antibody.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Immunization / Measles-Mumps-Rubella Vaccine / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Antigens, Viral Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Iran J Immunol Year: 2021 Document Type: Article Affiliation country: Iji.2021.87990.1843

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Immunization / Measles-Mumps-Rubella Vaccine / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Antigens, Viral Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Iran J Immunol Year: 2021 Document Type: Article Affiliation country: Iji.2021.87990.1843