Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?
Iran J Immunol
; 18(1): 47-53, 2021 03.
Article
in English
| MEDLINE | ID: covidwho-2091347
ABSTRACT
BACKGROUND:
Incidence and severity of SARS-CoV2 infection are significantly lower in children and teenagers proposing that certain vaccines, routinely administered to neonates and children may provide cross-protection against this emerging infection.OBJECTIVE:
To assess the cross-protection induced by prior measles, mumps and rubella (MMR) vaccinations against COVID-19.METHODS:
The antibody responses to MMR and tetanus vaccines were determined in 53 patients affected with SARS-CoV2 infection and 52 age-matched healthy subjects. Serum levels of antibodies specific for NP and RBD of SARS-CoV2 were also determined in both groups of subjects with ELISA.RESULTS:
Our results revealed significant differences in anti-NP (P<0.0001) and anti-RBD (P<0.0001) IgG levels between patients and healthy controls. While the levels of rubella- and mumps specific IgG were not different in the two groups of subjects, measles-specific IgG was significantly higher in patients (P<0.01). The serum titer of anti-tetanus antibody, however, was significantly lower in patients compared to healthy individuals (P<0.01).CONCLUSION:
Our findings suggest that measles vaccination triggers those B cells cross-reactive with SARS-CoV2 antigens leading to the production of increased levels of measles-specific antibody.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Immunoglobulin G
/
Immunization
/
Measles-Mumps-Rubella Vaccine
/
SARS-CoV-2
/
COVID-19
/
Antibodies, Viral
/
Antigens, Viral
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Vaccines
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Iran J Immunol
Year:
2021
Document Type:
Article
Affiliation country:
Iji.2021.87990.1843
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