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The effects of combination of Zingiber officinale and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients: a randomized controlled trial.
Mesri, Mehdi; Esmaeili Saber, Seied Saeid; Godazi, Mohammadreza; Roustaei Shirdel, Aboulfazl; Montazer, Reza; Koohestani, Hamid Reza; Baghcheghi, Nayereh; Karimy, Mahmood; Azizi, Nemat.
  • Mesri M; Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.
  • Esmaeili Saber SS; Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.
  • Godazi M; Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.
  • Roustaei Shirdel A; Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.
  • Montazer R; Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.
  • Koohestani HR; Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.
  • Baghcheghi N; Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.
  • Karimy M; Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.
  • Azizi N; Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.
J Complement Integr Med ; 18(4): 775-781, 2021 Mar 31.
Article in English | MEDLINE | ID: covidwho-1160235
Semantic information from SemMedBD (by NLM)
1. Suspected COVID-19 PROCESS_OF Outpatients
Subject
Suspected COVID-19
Predicate
PROCESS_OF
Object
Outpatients
2. Standard Treatment ADMINISTERED_TO Control Groups
Subject
Standard Treatment
Predicate
ADMINISTERED_TO
Object
Control Groups
3. Coughing PROCESS_OF Intervention Group
Subject
Coughing
Predicate
PROCESS_OF
Object
Intervention Group
4. Dyspnea PROCESS_OF Intervention Group
Subject
Dyspnea
Predicate
PROCESS_OF
Object
Intervention Group
5. Myalgia PROCESS_OF Intervention Group
Subject
Myalgia
Predicate
PROCESS_OF
Object
Intervention Group
6. Hospitalization COEXISTS_WITH Interventional procedure
Subject
Hospitalization
Predicate
COEXISTS_WITH
Object
Interventional procedure
7. COVID-19 PROCESS_OF Outpatients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Outpatients
8. Symptoms PROCESS_OF Outpatients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Outpatients
9. Suspected COVID-19 PROCESS_OF Outpatients
Subject
Suspected COVID-19
Predicate
PROCESS_OF
Object
Outpatients
10. Standard Treatment ADMINISTERED_TO Control Groups
Subject
Standard Treatment
Predicate
ADMINISTERED_TO
Object
Control Groups
11. Coughing PROCESS_OF Intervention Group
Subject
Coughing
Predicate
PROCESS_OF
Object
Intervention Group
12. Dyspnea PROCESS_OF Intervention Group
Subject
Dyspnea
Predicate
PROCESS_OF
Object
Intervention Group
13. Myalgia PROCESS_OF Intervention Group
Subject
Myalgia
Predicate
PROCESS_OF
Object
Intervention Group
14. Hospitalization COEXISTS_WITH Interventional procedure
Subject
Hospitalization
Predicate
COEXISTS_WITH
Object
Interventional procedure
15. COVID-19 PROCESS_OF Outpatients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Outpatients
16. Symptoms PROCESS_OF Outpatients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Outpatients
ABSTRACT

OBJECTIVES:

Herbal medicines, as a treatment method, have received a great deal of attention. The effects of two herbal medicines namely Zingiber officinale and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients were examined.

METHODS:

A clinical trial with 100 suspected COVID-19 outpatients as participants was conducted. The participants were allocated randomly to two groups of 50 members. The intervention group received concurrent Zingiber officinale (Tablet Vomigone 500 mg II tds) and Echinacea (Tablet Rucoldup I tds) for seven days in addition to the standard treatment. The control group only received the standard treatment (Hydroxychloroquine). After seven days, alleviation of clinical symptoms and hospitalization rate were examined. In addition, 14 days after treatment, the hospitalization was assessed again by telephone follow up.

RESULTS:

The two groups were identical in terms of basic characteristics. Improvement level as to coughing, dyspnea, and muscle pain was higher in the intervention group (p value <0.05). There was no significant difference between the two groups in terms of the other symptoms. In addition, the hospitalization rate in the intervention and control groups were 2 and 6% respectively, which are not significantly different (p value >0.05).

CONCLUSIONS:

Taking into account the efficiency and trivial side-effects of Zingiber officinale and Echinacea, using them for alleviation and control of the clinical symptoms in COVID-19 outpatients is recommended.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Echinacea / Ginger / COVID-19 Type of study: Controlled clinical trial / Diagnostic study / Observational study / Randomized controlled trials Topics: Traditional medicine Limits: Humans Language: English Journal: J Complement Integr Med Year: 2021 Document Type: Article Affiliation country: Jcim-2020-0283

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Echinacea / Ginger / COVID-19 Type of study: Controlled clinical trial / Diagnostic study / Observational study / Randomized controlled trials Topics: Traditional medicine Limits: Humans Language: English Journal: J Complement Integr Med Year: 2021 Document Type: Article Affiliation country: Jcim-2020-0283