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Nintedanib treatment for pulmonary fibrosis after coronavirus disease 2019.
Ogata, Hiroaki; Nakagawa, Taisuke; Sakoda, Soichiro; Ishimatsu, Akiko; Taguchi, Kazuhito; Kadowaki, Masako; Moriwaki, Atsushi; Yoshida, Makoto.
  • Ogata H; Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan.
  • Nakagawa T; Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan.
  • Sakoda S; Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan.
  • Ishimatsu A; Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan.
  • Taguchi K; Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan.
  • Kadowaki M; Department of Infectious Diseases National Hospital Organization Fukuoka National Hospital Fukuoka Japan.
  • Moriwaki A; Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan.
  • Yoshida M; Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan.
Respirol Case Rep ; 9(5): e00744, 2021 May.
Article in English | MEDLINE | ID: covidwho-1160366
Semantic information from SemMedBD (by NLM)
1. nintedanib TREATS Pulmonary Fibrosis
Subject
nintedanib
Predicate
TREATS
Object
Pulmonary Fibrosis
2. COVID-19 PRECEDES Pulmonary Fibrosis
Subject
COVID-19
Predicate
PRECEDES
Object
Pulmonary Fibrosis
3. Smoking History NEG_PROCESS_OF Woman
Subject
Smoking History
Predicate
NEG_PROCESS_OF
Object
Woman
4. Warburg Therapy USES Nasal Cannula
Subject
Warburg Therapy
Predicate
USES
Object
Nasal Cannula
5. methylprednisolone TREATS Respiration Disorders
Subject
methylprednisolone
Predicate
TREATS
Object
Respiration Disorders
6. nintedanib TREATS Patients
Subject
nintedanib
Predicate
TREATS
Object
Patients
7. Walking aid USES oxygen
Subject
Walking aid
Predicate
USES
Object
oxygen
8. nintedanib TREATS Pulmonary Fibrosis
Subject
nintedanib
Predicate
TREATS
Object
Pulmonary Fibrosis
9. COVID-19 PRECEDES Pulmonary Fibrosis
Subject
COVID-19
Predicate
PRECEDES
Object
Pulmonary Fibrosis
10. Smoking History NEG_PROCESS_OF Woman
Subject
Smoking History
Predicate
NEG_PROCESS_OF
Object
Woman
11. Warburg Therapy USES Nasal Cannula
Subject
Warburg Therapy
Predicate
USES
Object
Nasal Cannula
12. methylprednisolone TREATS Respiration Disorders
Subject
methylprednisolone
Predicate
TREATS
Object
Respiration Disorders
13. nintedanib TREATS Patients
Subject
nintedanib
Predicate
TREATS
Object
Patients
14. Walking aid USES oxygen
Subject
Walking aid
Predicate
USES
Object
oxygen
ABSTRACT
A 78-year-old Japanese woman with no smoking history suffered from near-fatal coronavirus disease 2019 (COVID-19) requiring four-week invasive mechanical ventilation, with subsequent radiological features of pulmonary fibrosis. Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy. In parallel with tapering systemic steroid, the patient was treated with nintedanib. Three months later, the patient was able to walk with a walking aid using oxygen at 4 L/min. The present case is an indication that nintedanib might provide a novel therapeutic approach for managing post-COVID-19 fibrosis, although further studies are warranted.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Topics: Long Covid Language: English Journal: Respirol Case Rep Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Topics: Long Covid Language: English Journal: Respirol Case Rep Year: 2021 Document Type: Article