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Polymer-based nano-therapies to combat COVID-19 related respiratory injury: progress, prospects, and challenges.
Rana, Md Mohosin.
  • Rana MM; Biomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada.
J Biomater Sci Polym Ed ; 32(9): 1219-1249, 2021 06.
Article in English | MEDLINE | ID: covidwho-1160539
ABSTRACT
The recent coronavirus disease-2019 (COVID-19) outbreak has increased at an alarming rate, representing a substantial cause of mortality worldwide. Respiratory injuries are major COVID-19 related complications, leading to poor lung circulation, tissue scarring, and airway obstruction. Despite an in-depth investigation of respiratory injury's molecular pathogenesis, effective treatments have yet to be developed. Moreover, early detection of viral infection is required to halt the disease-related long-term complications, including respiratory injuries. The currently employed detection technique (quantitative real-time polymerase chain reaction or qRT-PCR) failed to meet this need at some point because it is costly, time-consuming, and requires higher expertise and technical skills. Polymer-based nanobiosensing techniques can be employed to overcome these limitations. Polymeric nanomaterials have the potential for clinical applications due to their versatile features like low cytotoxicity, biodegradability, bioavailability, biocompatibility, and specific delivery at the targeted site of action. In recent years, innovative polymeric nanomedicine approaches have been developed to deliver therapeutic agents and support tissue growth for the inflamed organs, including the lung. This review highlights the most recent advances of polymer-based nanomedicine approaches in infectious disease diagnosis and treatments. This paper also focuses on the potential of novel nanomedicine techniques that may prove to be therapeutically efficient in fighting against COVID-19 related respiratory injuries.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Polymers / Nanostructures / Nanomedicine / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Diagnostic study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: J Biomater Sci Polym Ed Journal subject: Biomedical Engineering Year: 2021 Document Type: Article Affiliation country: 09205063.2021.1909412

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Polymers / Nanostructures / Nanomedicine / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Diagnostic study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: J Biomater Sci Polym Ed Journal subject: Biomedical Engineering Year: 2021 Document Type: Article Affiliation country: 09205063.2021.1909412