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Is SARS-CoV-2 vaccination safe and effective for elderly individuals with neurodegenerative diseases?
Shi, Yan; Guo, Minna; Yang, Wenjing; Liu, Shijiang; Zhu, Bin; Yang, Ling; Yang, Chun; Liu, Cunming.
  • Shi Y; Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing China.
  • Guo M; Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing China.
  • Yang W; Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing China.
  • Liu S; Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing China.
  • Zhu B; Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou China.
  • Yang L; Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou China.
  • Yang C; Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing China.
  • Liu C; Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing China.
Expert Rev Vaccines ; 20(4): 375-383, 2021 04.
Article in English | MEDLINE | ID: covidwho-1160718
ABSTRACT

INTRODUCTION:

Coronavirus Disease 2019 (COVID-19) poses a substantial threat to the lives of the elderly, especially those with neurodegenerative diseases, and vaccination against viral infections is recognized as an effective measure to reduce mortality. However, elderly patients with neurodegenerative diseases often suffer from abnormal immune function and take multiple medications, which may complicate the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines. Currently, there is no expert consensus on whether SARS-CoV-2 vaccines are suitable for patients with neurodegenerative diseases. AREAS COVERED We searched Pubmed to conduct a systematic review of published studies, case reports, reviews, meta-analyses, and expert guidelines on the impact of SARS-CoV-2 on neurodegenerative diseases and the latest developments in COVID-19 vaccines. We also summarized the interaction between vaccines and age-related neurodegenerative diseases. The compatibility of future SARS-CoV-2 vaccines with neurodegenerative diseases is discussed. EXPERT OPINION Vaccines enable the body to produce immunity by activating the body's immune response. The pathogenesis and treatment of neurodegenerative diseases is complex, and these diseases often involve abnormal immune function, which can substantially affect the safety and effectiveness of vaccines. In short, this article provides recommendations for the use of vaccine candidates in patients with neurodegenerative diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neurodegenerative Diseases / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines Limits: Aged / Humans Language: English Journal: Expert Rev Vaccines Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neurodegenerative Diseases / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines Limits: Aged / Humans Language: English Journal: Expert Rev Vaccines Journal subject: Allergy and Immunology Year: 2021 Document Type: Article