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Autopsy and Histologic Findings of Patients with New Coronavirus Pneumonia: The Pathologic Associations with Hypoxemia.
Zhang, Heng; Zhou, Jun; Chen, Rong; Ren, Yong; Cai, Jun; Zhao, Lei; Fei, Xiaochun; Liu, Zhenhua; Zhang, Yu; Yuan, Ling; Wang, Chaofu.
  • Zhang H; Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (mainland).
  • Zhou J; Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (mainland).
  • Chen R; Department of Pathology, Jin Yin-tan Hospital, Wuhan, Hubei, China (mainland).
  • Ren Y; Department of Pathology, General Hospital of Central Theater Command, People's Liberation Army (PLA), Wuhan, Hubei, China (mainland).
  • Cai J; Department of Pathology, Shanghai Jiaotong University School of Medicine, Shanghai, China (mainland).
  • Zhao L; Department of Pathology, Shanghai Jiaotong University School of Medicine, Shanghai, China (mainland).
  • Fei X; Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (mainland).
  • Liu Z; Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (mainland).
  • Zhang Y; Department of Pathology, General Hospital of Central Theater Command, People's Liberation Army (PLA), Wuhan, Hubei, China (mainland).
  • Yuan L; Department of Pathology, General Hospital of Central Theater Command, People's Liberation Army (PLA), Wuhan, Hubei, China (mainland).
  • Wang C; Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (mainland).
Med Sci Monit ; 27: e928837, 2021 Feb 13.
Article in English | MEDLINE | ID: covidwho-1161104
Semantic information from SemMedBD (by NLM)
1. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
2. Hypoxemia CAUSES Multiple Organ Failure
Subject
Hypoxemia
Predicate
CAUSES
Object
Multiple Organ Failure
3. Cessation of life PROCESS_OF Patients
Subject
Cessation of life
Predicate
PROCESS_OF
Object
Patients
4. 2019 novel coronavirus PROCESS_OF Patients
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Patients
5. Cadaver PART_OF Patients
Subject
Cadaver
Predicate
PART_OF
Object
Patients
6. ARCH PART_OF Aorta
Subject
ARCH
Predicate
PART_OF
Object
Aorta
7. Spleen LOCATION_OF Atrophic
Subject
Spleen
Predicate
LOCATION_OF
Object
Atrophic
8. Bone Marrow LOCATION_OF Erythropoiesis
Subject
Bone Marrow
Predicate
LOCATION_OF
Object
Erythropoiesis
9. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
10. Hypoxemia CAUSES Multiple Organ Failure
Subject
Hypoxemia
Predicate
CAUSES
Object
Multiple Organ Failure
11. Cessation of life PROCESS_OF Patients
Subject
Cessation of life
Predicate
PROCESS_OF
Object
Patients
12. 2019 novel coronavirus PROCESS_OF Patients
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Patients
13. Cadaver PART_OF Patients
Subject
Cadaver
Predicate
PART_OF
Object
Patients
14. ARCH PART_OF Aorta
Subject
ARCH
Predicate
PART_OF
Object
Aorta
15. Spleen LOCATION_OF Atrophic
Subject
Spleen
Predicate
LOCATION_OF
Object
Atrophic
16. Bone Marrow LOCATION_OF Erythropoiesis
Subject
Bone Marrow
Predicate
LOCATION_OF
Object
Erythropoiesis
ABSTRACT
BACKGROUND Coronavirus 2 (SARS-CoV-2) was declared a pandemic by the World Health Organization (WHO) in March 2020. To further reveal the pathologic associations between coronavirus and hypoxemia, we report the findings of 4 complete systematic autopsies of severe acute respiratory syndrome coronavirus 2-positive individuals who died of multiple organ failure caused by severe hypoxemia. MATERIAL AND METHODS We examined the donated corpses of 4 deceased patients who had been diagnosed with severe acute respiratory syndrome coronavirus 2. A complete post-mortem examination was carried out on each corpse, and multiple organs were macroscopically examined. RESULTS The 4 corpses were 2 males and 2 females, with an average age of 69 years. Bilateral lungs showed various degrees of atrophy and consolidation, with diffusely tough and solid texture in the sections. A thromboembolism was found in the main pulmonary artery extending into the atrium in 1 corpse, and significant atherosclerotic plaques tagged in the inner wall of the aortic arch were found in 2 corpses. Two corpses were found to have slightly atrophied bilateral renal parenchyma. Atrophic changes in the spleen were found in 2 corpses. Notably, there were significantly expanded alveolar septa and prominent fibroblastic proliferation. CONCLUSIONS The laboratory data of these corpses showed a progressive decrease in blood oxygen saturation, followed by refractory and irreversible hypoxemia. Clinical and laboratory information and autopsy and histologic presentations of multiple organs showed insufficient air exchange due to abnormalities in the respiratory system, and reduced erythropoiesis in bone marrow may play a role.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Autopsy / SARS-CoV-2 / COVID-19 / Hypoxia Type of study: Diagnostic study / Risk factors Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Med Sci Monit Journal subject: Medicine Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Autopsy / SARS-CoV-2 / COVID-19 / Hypoxia Type of study: Diagnostic study / Risk factors Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Med Sci Monit Journal subject: Medicine Year: 2021 Document Type: Article