Novel Negative Sense Genes in the RNA Genome of Coronaviruses.
Dokl Biochem Biophys
; 496(1): 27-31, 2021 May.
Article
in English
| MEDLINE | ID: covidwho-1161117
ABSTRACT
The coronavirus family consists of lipid-containing envelope viruses that have a single-stranded RNA genome that encodes 25-30 proteins in different viruses by the mechanism of positive-polarity strategy. In addition, extended open reading trnslation frames (ORFs, genes) located in a negative-sense orientation were found in the genomes of coronaviruses. The size of negative-sense genes varies in the range of 150-450 nt, which corresponds to polypeptides encoded by negative-polarity genes (negative gene proteins, NGP) with m. m. 5-30 × 103 kDa. Coronaviruses show marked differences from virus to virus in the number of negative genes detected. These negative-sense genes in the coronavirus genome allow this family to be considered as viruses developing an ambisense genome strategy.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA, Viral
/
Genomics
/
Genes, Viral
/
SARS-CoV-2
Language:
English
Journal:
Dokl Biochem Biophys
Journal subject:
Biophysics
/
Biochemistry
Year:
2021
Document Type:
Article
Affiliation country:
S1607672921010130
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