Psoriasis.
Lancet
; 397(10281): 1301-1315, 2021 04 03.
Article
in English
| MEDLINE | ID: covidwho-1161993
ABSTRACT
Psoriasis is a common, chronic papulosquamous skin disease occurring worldwide, presenting at any age, and leading to a substantial burden for individuals and society. It is associated with several important medical conditions, including depression, psoriatic arthritis, and cardiometabolic syndrome. Its most common form, chronic plaque or psoriasis vulgaris, is a consequence of genetic susceptibility, particularly in the presence of the HLA-C*0602 risk allele, and of environmental triggers such as streptococcal infection, stress, smoking, obesity, and alcohol consumption. There are several phenotypes and research has separated pustular from chronic plaque forms. Immunological and genetic studies have identified IL-17 and IL-23 as key drivers of psoriasis pathogenesis. Immune targeting of these cytokines and of TNFα by biological therapies has revolutionised the care of severe chronic plaque disease. Psoriasis cannot currently be cured, but management should aim to minimise physical and psychological harm by treating patients early in the disease process, identifying and preventing associated multimorbidity, instilling lifestyle modifications, and employing a personalised approach to treatment.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Psoriasis
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Lancet
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS