Molecular hydrogen (H2 ) as a potential treatment for acute and chronic fatigue.
Arch Pharm (Weinheim)
; 354(4): e2000378, 2021 Apr.
Article
in English
| MEDLINE | ID: covidwho-1162498
ABSTRACT
Many diseases as well as acute conditions can lead to fatigue, which can be either temporary or chronic in nature. Acute fatigue develops frequently after physical exercise or after alcohol hangover, whereas microbial infections such as influenza or COVID-19 and chronic diseases like Parkinson's disease or multiple sclerosis are often associated with chronic fatigue. Oxidative stress and a resulting disturbance of mitochondrial function are likely to be common denominators for many forms of fatigue, and antioxidant treatments have been shown to be effective in alleviating the symptoms of fatigue. In this study, we review the role of reactive oxygen and nitrogen species in fatigue and the antioxidant effects of the intake of molecular hydrogen. We propose that molecular hydrogen is well suited for the treatment of temporary and chronic forms of oxidative stress-associated fatigue.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Oxidative Stress
/
Fatigue
/
COVID-19
/
Hydrogen
Limits:
Humans
Language:
English
Journal:
Arch Pharm (Weinheim)
Year:
2021
Document Type:
Article
Affiliation country:
Ardp.202000378
Similar
MEDLINE
...
LILACS
LIS