Toward an understanding of regulatory T cells in COVID-19: A systematic review.
J Med Virol
; 93(7): 4167-4181, 2021 Jul.
Article
in English
| MEDLINE | ID: covidwho-1162826
ABSTRACT
A more detailed understanding of Treg cells in COVID-19 infection will broaden our knowledge of the COVID-19 immunopathology and give us more insight into the curative immune-based strategies. We systematically searched electronic databases (PubMed, Google Scholar, EMBASE) and identified 18 eligible studies. Despite the inconsistencies between the results, we observed a trend toward decreasing Treg levels in severe COVID-19 patients. This finding underlines the hypothesis that Tregs play a role in the pathogenesis of COVID-19. Further studies on Tregs' functional aspects are necessary to illustrate Tregs' potential role in COVID-19 disease.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
T-Lymphocytes, Regulatory
/
SARS-CoV-2
/
COVID-19
Type of study:
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
J Med Virol
Year:
2021
Document Type:
Article
Affiliation country:
Jmv.26891
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