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SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization.
Hoffmann, Markus; Zhang, Lu; Krüger, Nadine; Graichen, Luise; Kleine-Weber, Hannah; Hofmann-Winkler, Heike; Kempf, Amy; Nessler, Stefan; Riggert, Joachim; Winkler, Martin Sebastian; Schulz, Sebastian; Jäck, Hans-Martin; Pöhlmann, Stefan.
  • Hoffmann M; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany; Faculty of Biology and Psychology, University Göttingen, Wilhelmsplatz 1, 37073 Göttingen, Germany. Electronic address: mhoffmann@dpz.eu.
  • Zhang L; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany; Faculty of Biology and Psychology, University Göttingen, Wilhelmsplatz 1, 37073 Göttingen, Germany.
  • Krüger N; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany.
  • Graichen L; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany.
  • Kleine-Weber H; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany; Faculty of Biology and Psychology, University Göttingen, Wilhelmsplatz 1, 37073 Göttingen, Germany.
  • Hofmann-Winkler H; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany.
  • Kempf A; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany; Faculty of Biology and Psychology, University Göttingen, Wilhelmsplatz 1, 37073 Göttingen, Germany.
  • Nessler S; Institute of Neuropathology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany.
  • Riggert J; Department of Transfusion Medicine, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany.
  • Winkler MS; Department of Anaesthesiology and Intensive Care Medicine, University of Göttingen Medical Center, Göttingen, Georg-August University of Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany.
  • Schulz S; Division of Molecular Immunology, Department of Internal Medicine 3, Friedrich-Alexander University of Erlangen-Nürnberg, Glückstraße 6, 91054 Erlangen, Germany.
  • Jäck HM; Division of Molecular Immunology, Department of Internal Medicine 3, Friedrich-Alexander University of Erlangen-Nürnberg, Glückstraße 6, 91054 Erlangen, Germany.
  • Pöhlmann S; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany; Faculty of Biology and Psychology, University Göttingen, Wilhelmsplatz 1, 37073 Göttingen, Germany. Electronic address: spoehlmann@dpz.eu.
Cell Rep ; 35(3): 109017, 2021 04 20.
Article in English | MEDLINE | ID: covidwho-1163486
Preprint
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ABSTRACT
Transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans to farmed mink has been observed in Europe and the US. In the infected animals, viral variants arose that harbored mutations in the spike (S) protein, the target of neutralizing antibodies, and these variants were transmitted back to humans. This raised concerns that mink might become a constant source of human infection with SARS-CoV-2 variants associated with an increased threat to human health and resulted in mass culling of mink. Here, we report that mutations frequently found in the S proteins of SARS-CoV-2 from mink are mostly compatible with efficient entry into human cells and its inhibition by soluble angiotensin-converting enzyme 2 (ACE2). In contrast, mutation Y453F reduces neutralization by an antibody with emergency use authorization for coronavirus disease 2019 (COVID-19) therapy and sera/plasma from COVID-19 patients. These results suggest that antibody responses induced upon infection or certain antibodies used for treatment might offer insufficient protection against SARS-CoV-2 variants from mink.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Mink / Antibodies, Viral Topics: Variants Limits: Animals / Humans Language: English Journal: Cell Rep Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Mink / Antibodies, Viral Topics: Variants Limits: Animals / Humans Language: English Journal: Cell Rep Year: 2021 Document Type: Article