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An investigation for airflow and deposition of PM2.5 contaminated with SAR-CoV-2 virus in healthy and diseased human airway.
Chen, Wei-Hsin; Mutuku, Justus Kavita; Yang, Zhe-Wei; Hwang, Chii-Jong; Lee, Wen Jhy; Ashokkumar, Veeramuthu.
  • Chen WH; Department of Aeronautics and Astronautics, National Cheng Kung University, Tainan, 701, Taiwan; Research Center for Smart Sustainable Circular Economy, Tunghai University, Taichung, 407, Taiwan; Department of Mechanical Engineering, National Chin-Yi University of Technology, Taichung, 411, Taiwan.
  • Mutuku JK; Center for Environmental Toxin and Emerging- Contaminant Research, Cheng Shiu University, Taiwan; Super Micro Research and Technology Center, Cheng Shiu University, Taiwan; Department of Environmental Engineering, National Cheng Kung University, Tainan, 701, Taiwan.
  • Yang ZW; Department of Aeronautics and Astronautics, National Cheng Kung University, Tainan, 701, Taiwan.
  • Hwang CJ; Department of Aeronautics and Astronautics, National Cheng Kung University, Tainan, 701, Taiwan.
  • Lee WJ; Department of Environmental Engineering, National Cheng Kung University, Tainan, 701, Taiwan.
  • Ashokkumar V; Center of Excellence in Catalysis for Bioenergy and Renewable Chemicals (CBRC), Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Environ Res ; 197: 111096, 2021 06.
Article in English | MEDLINE | ID: covidwho-1163738
Semantic information from SemMedBD (by NLM)
1. Airway structure PART_OF Homo sapiens
Subject
Airway structure
Predicate
PART_OF
Object
Homo sapiens
2. Airway structure LOCATION_OF 10 - 12
Subject
Airway structure
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LOCATION_OF
Object
10 - 12
3. Expiratio PROCESS_OF C0030551
Subject
Expiratio
Predicate
PROCESS_OF
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C0030551
4. Desmosine AUGMENTS Impacted tooth
Subject
Desmosine
Predicate
AUGMENTS
Object
Impacted tooth
5. Airway structure PART_OF Homo sapiens
Subject
Airway structure
Predicate
PART_OF
Object
Homo sapiens
6. Airway structure LOCATION_OF 10 - 12
Subject
Airway structure
Predicate
LOCATION_OF
Object
10 - 12
7. Expiration, function PROCESS_OF parent
Subject
Expiration, function
Predicate
PROCESS_OF
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parent
8. Desmosine AUGMENTS Impacted tooth
Subject
Desmosine
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AUGMENTS
Object
Impacted tooth
ABSTRACT
This study is motivated by the amplified transmission rates of the SAR-CoV-2 virus in areas with high concentrations of fine particulates (PM2.5) as reported in northern Italy and Mexico. To develop a deeper understanding of the contribution of PM2.5 in the propagation of the SAR-CoV-2 virus in the population, the deposition patterns and efficiencies (DEs) of PM2.5 laced with the virus in healthy and asthmatic airways are studied. Physiologically correct 3-D models for generations 10-12 of the human airways are applied to carry out a numerical analysis of two-phase flow for full breathing cycles. Two concentrations of PM2.5 are applied for the simulation, i.e., 30 µg⋅m-3 and 80 µg⋅m-3 for three breathing statuses, i.e., rest, light exercise, and moderate activity. All the PM2.5 injected into the control volume is assumed to be 100% contaminated with the SAR-CoV-2 virus. Skewed air-flow phenomena at the bifurcations are proportional to the Reynolds number at the inlet, and their intensity in the asthmatic airway exceeded that of the healthy one. Upon exhalation, two peak air-flow vectors from daughter branches combine to form one big vector in the parent generation. Asthmatic airway models has higher deposition efficiencies (DEs) for contaminated PM2.5 as compared to the healthy one. Higher DEs arise in the asthmatic airway model due to complex secondary flows which increase the impaction of contaminated PM2.5 on airways' walls.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Lung Limits: Humans Country/Region as subject: Europa / Mexico Language: English Journal: Environ Res Year: 2021 Document Type: Article Affiliation country: J.envres.2021.111096

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Lung Limits: Humans Country/Region as subject: Europa / Mexico Language: English Journal: Environ Res Year: 2021 Document Type: Article Affiliation country: J.envres.2021.111096