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Alterations in T and B cell function persist in convalescent COVID-19 patients.
Shuwa, Halima A; Shaw, Tovah N; Knight, Sean B; Wemyss, Kelly; McClure, Flora A; Pearmain, Laurence; Prise, Ian; Jagger, Christopher; Morgan, David J; Khan, Saba; Brand, Oliver; Mann, Elizabeth R; Ustianowski, Andrew; Bakerly, Nawar Diar; Dark, Paul; Brightling, Christopher E; Brij, Seema; Felton, Timothy; Simpson, Angela; Grainger, John R; Hussell, Tracy; Konkel, Joanne E; Menon, Madhvi.
  • Shuwa HA; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Graf
  • Shaw TN; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Graf
  • Knight SB; Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3FL, UK.
  • Wemyss K; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Graf
  • McClure FA; Department of Respiratory Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.
  • Pearmain L; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Graf
  • Prise I; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Graf
  • Jagger C; Wellcome Trust Centre for Cell Matrix Research, The University of Manchester, Manchester M13 9PT, UK.
  • Morgan DJ; Division of Infection, Immunity, and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, Manchester, UK.
  • Khan S; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Graf
  • Brand O; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Graf
  • Mann ER; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Graf
  • Ustianowski A; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Graf
  • Bakerly ND; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Graf
  • Dark P; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Graf
  • Brightling CE; Maternal and Fetal Health Centre, Division of Developmental Biology, School of Medical Sciences, Faculty of Biology, Medicine, and Health, The University of Manchester, 5th Floor, St. Mary's Hospital, Oxford Road, Manchester M13 9WL, UK.
  • Brij S; Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, UK.
  • Felton T; Division of Infection, Immunity, and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, Manchester, UK.
  • Simpson A; Intensive Care Department, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.
  • Grainger JR; Department of Respiratory Sciences, University of Leicester, Leicester LE3 9QP, UK.
  • Hussell T; Department of Respiratory Medicine, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, UK.
  • Menon M; Division of Infection, Immunity, and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, Manchester, UK.
Med (N Y) ; 2(6): 720-735.e4, 2021 06 11.
Article in English | MEDLINE | ID: covidwho-1164202
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Patients
3. Immune response PROCESS_OF Patients
Subject
Immune response
Predicate
PROCESS_OF
Object
Patients
4. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
5. Lymphocyte LOCATION_OF Subgroup A Nepoviruses
Subject
Lymphocyte
Predicate
LOCATION_OF
Object
Subgroup A Nepoviruses
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Patients
8. Immune response PROCESS_OF Patients
Subject
Immune response
Predicate
PROCESS_OF
Object
Patients
9. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
10. Lymphocyte LOCATION_OF Subgroup A Nepoviruses
Subject
Lymphocyte
Predicate
LOCATION_OF
Object
Subgroup A Nepoviruses
ABSTRACT

BACKGROUND:

Emerging studies indicate that some coronavirus disease 2019 (COVID-19) patients suffer from persistent symptoms, including breathlessness and chronic fatigue; however, the long-term immune response in these patients presently remains ill-defined.

METHODS:

Here, we describe the phenotypic and functional characteristics of B and T cells in hospitalized COVID-19 patients during acute disease and at 3-6 months of convalescence.

FINDINGS:

We report that the alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients. In contrast, T cells from convalescent patients displayed continued alterations with persistence of a cytotoxic program evident in CD8+ T cells as well as elevated production of type 1 cytokines and interleukin-17 (IL-17). Interestingly, B cells from patients with acute COVID-19 displayed an IL-6/IL-10 cytokine imbalance in response to Toll-like receptor activation, skewed toward a pro-inflammatory phenotype. Whereas the frequency of IL-6+ B cells was restored in convalescent patients irrespective of clinical outcome, the recovery of IL-10+ B cells was associated with the resolution of lung pathology.

CONCLUSIONS:

Our data detail lymphocyte alterations in previously hospitalized COVID-19 patients up to 6 months following hospital discharge and identify 3 subgroups of convalescent patients based on distinct lymphocyte phenotypes, with 1 subgroup associated with poorer clinical outcome. We propose that alterations in B and T cell function following hospitalization with COVID-19 could affect longer-term immunity and contribute to some persistent symptoms observed in convalescent COVID-19 patients.

FUNDING:

Provided by UKRI, Lister Institute of Preventative Medicine, the Wellcome Trust, The Kennedy Trust for Rheumatology Research, and 3M Global Giving.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Med (N Y) Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Med (N Y) Year: 2021 Document Type: Article