Your browser doesn't support javascript.
Correlation of Seizure Increase and COVID-19 Outbreak in Adult Patients with Epilepsy: Findings and Suggestions from a Nationwide Multi-centre Survey in China.
Zeng, Chang; Meng, Hongmei; Zhu, Yulan; Yao, Lifen; Lian, Yajun; Zhu, Yanmei; Zhang, Min; Dai, Yuwei; Wang, Kang; Han, Xiong; Li, Ling; Zhang, Lifang; Xu, Huiqing; Yao, Dongai; Luo, Xinmin; Jiang, Wen; Wang, Xiahong; Zhao, Chuansheng; Chen, Yangmei; Deng, Xuejun; Liu, Chaorong; Feng, Li; Song, Yanmin; Wu, Yuan; Liao, Weiping; Wang, Furong; Zhu, Suiqiang; Xiao, Bo; Wang, Qun; Long, Lili.
  • Zeng C; Health Management Center, Xiangya Hospital, Central South University, Changsha, China.
  • Meng H; Department of Neurology, The First Hospital of Jilin University, Changchun, China.
  • Zhu Y; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Yao L; Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Lian Y; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Zhu Y; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Zhang M; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Dai Y; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Wang K; Department of Neurology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
  • Han X; Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, China.
  • Li L; Department of Neurology, Qilu Hospital of Shandong University, Jinan, China.
  • Zhang L; Department of Neurology, Changzhi People's Hospital Affiliated to Changzhi Medical College, Changzhi, China.
  • Xu H; Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Yao D; Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Luo X; Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
  • Jiang W; Department of Neurology, Xijing Hospital, Air Force Military Medical University, Xi'an, China.
  • Wang X; Department of Neurology, Zhengzhou Second Hospital, Zhengzhou, China.
  • Zhao C; Department of Neurology, The First Hospital of China Medical University, Shenyang, China.
  • Chen Y; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Deng X; Department of Neurology, Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
  • Liu C; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Feng L; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Song Y; Department of Emergency, Xiangya Hospital, Central South University, Changsha, China.
  • Wu Y; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Liao W; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Institute, Department of Neurology of The Second Affiliated Hospital of Guangzhou Medical University, of Neuroscience, Province and the Ministry of Education of China, Guangzhou, China.
  • Wang F; Department of Neurology, Tongji Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
  • Zhu S; Department of Neurology, Tongji Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
  • Xiao B; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Wang Q; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address: qwang64@163.com.
  • Long L; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China. Electronic address: longlili1982@126.com.
Seizure ; 88: 102-108, 2021 May.
Article in English | MEDLINE | ID: covidwho-1164463
Semantic information from SemMedBD (by NLM)
1. Epilepsy PROCESS_OF Patients
Subject
Epilepsy
Predicate
PROCESS_OF
Object
Patients
2. Epilepsy PROCESS_OF Persons
Subject
Epilepsy
Predicate
PROCESS_OF
Object
Persons
3. IMPACT gene AFFECTS Epilepsy
Subject
IMPACT gene
Predicate
AFFECTS
Object
Epilepsy
4. IMPACT gene AUGMENTS Seizures
Subject
IMPACT gene
Predicate
AUGMENTS
Object
Seizures
5. Epilepsy COEXISTS_WITH Crisis
Subject
Epilepsy
Predicate
COEXISTS_WITH
Object
Crisis
6. Fit frequency COEXISTS_WITH COVID-19
Subject
Fit frequency
Predicate
COEXISTS_WITH
Object
COVID-19
7. Epilepsy PROCESS_OF Patients
Subject
Epilepsy
Predicate
PROCESS_OF
Object
Patients
8. Epilepsy PROCESS_OF Persons
Subject
Epilepsy
Predicate
PROCESS_OF
Object
Persons
9. IMPACT gene AFFECTS Epilepsy
Subject
IMPACT gene
Predicate
AFFECTS
Object
Epilepsy
10. IMPACT gene AUGMENTS Seizures
Subject
IMPACT gene
Predicate
AUGMENTS
Object
Seizures
11. Epilepsy COEXISTS_WITH Crisis
Subject
Epilepsy
Predicate
COEXISTS_WITH
Object
Crisis
12. Fit frequency COEXISTS_WITH COVID-19
Subject
Fit frequency
Predicate
COEXISTS_WITH
Object
COVID-19
ABSTRACT

OBJECTIVES:

To investigate the impact of the COVID-19 outbreak on the behaviours, mental health and seizure control of adult patients with epilepsy (PWE) and to identify the correlation of seizure increase and the COVID-19 outbreak to guide the medical care of individuals with epilepsy during a public health crisis.

METHODS:

This study was conducted at 28 centres from February 2020 to April 2020. Participants filled out a 62-item online survey including sociodemographic, COVID-19-related, epilepsy-related and psychological variables and were divided into two groups based on whether their seizure frequency increased during the COVID-19 pandemic. Chi-square tests and t-tests were used to test differences in significant characteristics. Multiple logistic regression analyses were used to identify risk factors for seizure worsening.

RESULTS:

A total of 1,237 adult PWE were enrolled for analysis. Of this sample, 31 (8.33%) patients experienced an increase in seizures during the pandemic. Multivariate logistic regression suggested that feeling nervous about the pandemic (P < 0.05), poor quality of life (P = 0.001), drug reduction/withdrawal (P = 0.032), moderate anxiety during the COVID-19 outbreak (P = 0.046) and non-seizure free before the COVID-19 outbreak (P < 0.05) were independently related to seizure increase during the pandemic.

CONCLUSIONS:

During the COVID-19 pandemic, PWE with poor quality of life and mental status, as well as AED reduction/withdrawal, were more likely to experience seizure increase. This observation highlights the importance of early identification of the population at high risk of seizure worsening and implementation of preventive strategies during the pandemic.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Quality of Life / Seizures / Epilepsy / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Seizure Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: J.seizure.2021.03.029

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Quality of Life / Seizures / Epilepsy / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Seizure Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: J.seizure.2021.03.029