Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster.
Signal Transduct Target Ther
; 6(1): 136, 2021 03 31.
Article
in English
| MEDLINE | ID: covidwho-1164823
ABSTRACT
Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness. To experimentally demonstrate the epidemiological results, we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2. Remarkably, high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss, weakness, piloerection, hunched back and abdominal respiration, as well as severe pneumonia, pulmonary edema, consolidation, and fibrosis. In contrast with the males, the female hamsters showed much lower shedding viral titers, moderate symptoms, and relatively mild lung pathogenesis. The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Sex Characteristics
/
SARS-CoV-2
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Signal Transduct Target Ther
Year:
2021
Document Type:
Article
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