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Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2.
Ebinger, Joseph E; Fert-Bober, Justyna; Printsev, Ignat; Wu, Min; Sun, Nancy; Prostko, John C; Frias, Edwin C; Stewart, James L; Van Eyk, Jennifer E; Braun, Jonathan G; Cheng, Susan; Sobhani, Kimia.
  • Ebinger JE; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Fert-Bober J; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Printsev I; Advanced Clinical Biosystems Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Wu M; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Sun N; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Prostko JC; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Frias EC; Applied Research and Technology, Abbott Diagnostics, Abbott Park, IL, USA.
  • Stewart JL; Applied Research and Technology, Abbott Diagnostics, Abbott Park, IL, USA.
  • Van Eyk JE; Applied Research and Technology, Abbott Diagnostics, Abbott Park, IL, USA.
  • Braun JG; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Cheng S; Advanced Clinical Biosystems Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Sobhani K; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. jonathan.braun2@cshs.org.
Nat Med ; 27(6): 981-984, 2021 06.
Article in English | MEDLINE | ID: covidwho-1164882
ABSTRACT
In a cohort of BNT162b2 (Pfizer-BioNTech) mRNA vaccine recipients (n = 1,090), we observed that spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses elicited by a single vaccine dose in individuals with prior SARS-CoV-2 infection (n = 35) were similar to those seen after two doses of vaccine in individuals without prior infection (n = 228). Post-vaccine symptoms were more prominent for those with prior infection after the first dose, but symptomology was similar between groups after the second dose.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Immunoglobulin M / Spike Glycoprotein, Coronavirus / Coronavirus Nucleocapsid Proteins / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Antigens, Viral Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Nat Med Journal subject: Molecular Biology / Medicine Year: 2021 Document Type: Article Affiliation country: S41591-021-01325-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Immunoglobulin M / Spike Glycoprotein, Coronavirus / Coronavirus Nucleocapsid Proteins / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Antigens, Viral Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Nat Med Journal subject: Molecular Biology / Medicine Year: 2021 Document Type: Article Affiliation country: S41591-021-01325-6