Clinical features and risk factors associated with severe COVID-19 patients in China.
Chin Med J (Engl)
; 134(8): 944-953, 2021 Apr 01.
Article
in English
| MEDLINE | ID: covidwho-1165520
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread throughout the world. In this study, we aimed to identify the risk factors for severe COVID-19 to improve treatment guidelines.METHODS:
A multicenter, cross-sectional study was conducted on 313 patients hospitalized with COVID-19. Patients were classified into two groups based on disease severity (nonsevere and severe) according to initial clinical presentation. Laboratory test results and epidemiological and clinical characteristics were analyzed using descriptive statistics. Univariate and multivariate logistic regression models were used to detect potential risk factors associated with severe COVID-19.RESULTS:
A total of 289 patients (197 nonsevere and 92 severe cases) with a median age of 45.0 (33.0, 61.0) years were included in this study, and 53.3% (154/289) were male. Fever (192/286, 67.1%) and cough (170/289, 58.8%) were commonly observed, followed by sore throat (49/289, 17.0%). Multivariate logistic regression analysis suggested that patients who were aged ≥ 65 years (OR 2.725, 95% confidence interval [CI] 1.317-5.636; Pâ=â0.007), were male (OR 1.878, 95% CI 1.002-3.520, Pâ=â0.049), had comorbid diabetes (OR 3.314, 95% CI 1.126-9.758, Pâ=â0.030), cough (OR 3.427, 95% CI 1.752-6.706, Pâ<â0.001), and/or diarrhea (OR 2.629, 95% CI 1.109-6.231, Pâ=â0.028) on admission had a higher risk of severe disease. Moreover, stratification analysis indicated that male patients with diabetes were more likely to have severe COVID-19 (71.4% vs. 28.6%, χ2â=â8.183, Pâ=â0.004).CONCLUSIONS:
The clinical characteristics of those with severe and nonsevere COVID-19 were significantly different. The elderly, male patients with COVID-19, diabetes, and presenting with cough and/or diarrhea on admission may require close monitoring to prevent deterioration.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
English
Journal:
Chin Med J (Engl)
Year:
2021
Document Type:
Article
Affiliation country:
Cm9.0000000000001466
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