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The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis.
Martinez-Perez, Oscar; Prats Rodriguez, Pilar; Muner Hernandez, Marta; Encinas Pardilla, Maria Begoña; Perez Perez, Noelia; Vila Hernandez, Maria Rosa; Villalba Yarza, Ana; Nieto Velasco, Olga; Del Barrio Fernandez, Pablo Guillermo; Forcen Acebal, Laura; Orizales Lago, Carmen Maria; Martinez Varea, Alicia; Muñoz Abellana, Begoña; Suarez Arana, Maria; Fuentes Ricoy, Laura; Martinez Diago, Clara; Janeiro Freire, Maria Jesus; Alférez Alvarez-Mallo, Macarena; Casanova Pedraz, Cristina; Alomar Mateu, Onofre; Lesmes Heredia, Cristina; Wizner de Alva, Juan Carlos; Bernardo Vega, Rut; Macia Badia, Montserrat; Alvarez Colomo, Cristina; Sanchez Muñoz, Antonio; Pratcorona Alicart, Laia; Alonso Saiz, Ruben; Lopez Rodriguez, Monica; Del Carmen Barbancho Lopez, Maria; Meca Casbas, Marta Ruth; Vaquerizo Ruiz, Oscar; Moran Antolin, Eva; Nuñez Valera, Maria Jose; Fernandez Fernandez, Camino; Tubau Navarra, Albert; Cano Garcia, Alejandra Maria; Baena Luque, Carmen; Soldevilla Perez, Susana; Gastaca Abasolo, Irene; Adanez Garcia, Jose; Teulon Gonzalez, Maria; Puertas Prieto, Alberto; Ostos Serna, Rosa; Del Pilar Guadix Martin, Maria; Catalina Coello, Monica; Ferriols Perez, Elena; Caño Aguilar, Africa; De la Cruz Conty, Maria Luisa; Sainz Bueno, Jose Antonio.
  • Martinez-Perez O; Department Gynaecology and Obstetrics, Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Madrid, Spain. Oscarmartinezgine@gmail.com.
  • Prats Rodriguez P; Department Reproductive Medicine and Gynaecology, Obstetrics, Dexeus University Hospital, Barcelona, Catalunya, Spain.
  • Muner Hernandez M; Department Gynaecology and Obstetrics, La Paz University Hospital. Madrid, Madrid, Spain.
  • Encinas Pardilla MB; Department Gynaecology and Obstetrics, Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Madrid, Spain.
  • Perez Perez N; Department Gynaecology and Obstetrics, San Carlos University Hospital. Madrid, Madrid, Spain.
  • Vila Hernandez MR; Department Gynaecology and Obstetrics, Santa Caterina Hospital, Girona, Catalunya, Spain.
  • Villalba Yarza A; Department Gynaecology and Obstetrics, University Hospital of Salamanca, Salamanca, Castilla y León, Spain.
  • Nieto Velasco O; Department Obstetrics and Gynaecology, Quironsalud Madrid University Hospital. Madrid, Madrid, Spain.
  • Del Barrio Fernandez PG; Department Gynaecology and Obstetrics, Getafe University Hospital, Getafe, Madrid, Spain.
  • Forcen Acebal L; Department Gynaecology and Obstetrics, Doce de Octubre University Hospital, Comunidad de Madrid, Madrid, Spain.
  • Orizales Lago CM; Department Gynaecology and Obstetrics, Severo Ochoa University Hospital, Leganes, Madrid, Spain.
  • Martinez Varea A; Department Gynaecology and Obstetrics, La Fe University and Polytechnic Hospital, Comunidad Valenciana, Valencia, Spain.
  • Muñoz Abellana B; Department Obstetrics and Gynaecology, Sant Joan de Reus University Hospital, Reus, Catalunya, Spain.
  • Suarez Arana M; Department Gynaecology and Obstetrics, Regional University Hospital of Malaga, Malaga, Andalucía, Spain.
  • Fuentes Ricoy L; Department Obstetrics and Gynaecology, University Hospital of Ferrol, Ferrol, A Coruña, Spain.
  • Martinez Diago C; Department Gynaecology and Obstetrics, Doctor Josep Trueta University Hospital of Girona, Girona, Catalunya, Spain.
  • Janeiro Freire MJ; Department Obstetrics and Gynaecology, University Hospital Complex of A Coruña, A Coruña, Spain.
  • Alférez Alvarez-Mallo M; Department Obstetrics and Gynaecology, HM Hospitals, Madrid, Spain.
  • Casanova Pedraz C; Department Gynaecology and Obstetrics, University Hospital of Torrejon, Torrejon de Ardoz, Madrid, Spain.
  • Alomar Mateu O; Department Obstetrics and Gynaecology, Regional Hospital of Inca, Inca, Illes Balears, Spain.
  • Lesmes Heredia C; Department Obstetrics and Gynaecology, Parc Taulí Hospital, Barcelona, Catalunya, Spain.
  • Wizner de Alva JC; Department Gynaecology and Obstetrics, San Pedro de Alcántara Hospital, Caceres, Extremadura, Spain.
  • Bernardo Vega R; Department Gynaecology and Obstetrics, Rio Hortega University Hospital, Valladolid, Castilla y León, Spain.
  • Macia Badia M; Department Gynaecology and Obstetrics, Arnau de Vilanova University Hospital, Lleida, Catalunya, Spain.
  • Alvarez Colomo C; Department Gynaecology and Obstetrics, Valladolid University Hospital, Valladolid, Castilla y León, Spain.
  • Sanchez Muñoz A; Department Gynaecology and Obstetrics, General University Hospital of Ciudad Real, Ciudad Real, Castilla-La Mancha, Spain.
  • Pratcorona Alicart L; Department Obstetrics and Gynaecology, Germans Trias i Pujol University Hospital, Barcelona, Catalunya, Spain.
  • Alonso Saiz R; Department Gynaecology and Obstetrics, University Hospital of Burgos, Burgos, Castilla y León, Spain.
  • Lopez Rodriguez M; Department Obstetrics and Gynaecology, Joan XXIII University Hospital of Tarragona, Tarragona, Catalunya, Spain.
  • Del Carmen Barbancho Lopez M; Department Gynaecology and Obstetrics, Infanta Sofia University Hospital, San Sebastian de los Reyes, Madrid, Spain.
  • Meca Casbas MR; Department Obstetrics and Gynaecology, Poniente Hospital of Almería, El Ejido, Andalucía, Spain.
  • Vaquerizo Ruiz O; Department Obstetrics and Gynaecology, University Hospital of Cabueñes, Gijon, Asturias, Spain.
  • Moran Antolin E; Department Obstetrics and Gynaecology, Son Espases University Hospital, Palma de Mallorca, Illes Balears, Spain.
  • Nuñez Valera MJ; Department Obstetrics and Gynaecology, Virgen de la Luz Hospital, Cuenca, Castilla-La Mancha, Spain.
  • Fernandez Fernandez C; Department Gynaecology and Obstetrics, University Assistance Complex of Leon, Leon, Castilla y Leon, Spain.
  • Tubau Navarra A; Department Obstetrics and Gynaecology, Son Llatzer University Hospital, Palma de Mallorca, Illes Balears, Spain.
  • Cano Garcia AM; Department Gynaecology and Obstetrics, University Hospital of El Tajo, Aranjuez, Madrid, Spain.
  • Baena Luque C; Department Gynaecology and Obstetrics, Infanta Margarita Hospital, Andalucía, Cabra, Spain.
  • Soldevilla Perez S; Department Obstetrics and Gynaecology, University Hospital of Jerez de la Frontera, Jerez de la Frontera, Andalucía, Spain.
  • Gastaca Abasolo I; Department Obstetrics and Gynaecology, Txagorritxu University Hospital of Araba, Vitoria-Gasteiz, País Vasco, Spain.
  • Adanez Garcia J; Department Obstetrics and Gynaecology, Central University Hospital of Asturias, Oviedo, Asturias, Spain.
  • Teulon Gonzalez M; Department Gynaecology and Obstetrics, University Hospital of Fuenlabrada, Fuenlabrada, Madrid, Spain.
  • Puertas Prieto A; Department Obstetrics and Gynaecology, Virgen de las Nieves University Hospital, Granada, Andalucía, Spain.
  • Ostos Serna R; Department Gynaecology and Obstetrics, Virgen de Valme University Hospital, Sevilla, Andalucía, Spain.
  • Del Pilar Guadix Martin M; Department Obstetrics and Gynaecology, Virgen Macarena University Hospital, Sevilla, Andalucía, Spain.
  • Catalina Coello M; Department Gynaecology and Obstetrics, Virgen de la Concha Hospital, Zamora, Castilla y León, Spain.
  • Ferriols Perez E; Department Gynaecology and Obstetrics, Parc de Salut Mar University Hospital, Barcelona, Catalunya, Spain.
  • Caño Aguilar A; Department Obstetrics and Gynaecology, San Cecilio University Hospital of Granada, Granada, Andalucía, Spain.
  • De la Cruz Conty ML; Fundación de Investigación Biomédica, Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Madrid, Spain.
  • Sainz Bueno JA; Department Gynaecology and Obstetrics, University of Seville, G. Chacon (Viamed Santa Angela de la Cruz Hospital), Sevilla, Andalucia, Spain.
BMC Pregnancy Childbirth ; 21(1): 273, 2021 Apr 01.
Article in English | MEDLINE | ID: covidwho-1166895
ABSTRACT

BACKGROUND:

To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the cause of COVID-19 disease) exposure in pregnancy, compared to non-exposure, is associated with infection-related obstetric morbidity.

METHODS:

We conducted a multicentre prospective study in pregnancy based on a universal antenatal screening program for SARS-CoV-2 infection. Throughout Spain 45 hospitals tested all women at admission on delivery ward using polymerase-chain-reaction (PCR) for COVID-19 since late March 2020. The cohort of positive mothers and the concurrent sample of negative mothers was followed up until 6-weeks post-partum. Multivariable logistic regression analysis, adjusting for known confounding variables, determined the adjusted odds ratio (aOR) with 95% confidence intervals (95% CI) of the association of SARS-CoV-2 infection and obstetric outcomes. MAIN OUTCOME

MEASURES:

Preterm delivery (primary), premature rupture of membranes and neonatal intensive care unit admissions.

RESULTS:

Among 1009 screened pregnancies, 246 were SARS-CoV-2 positive. Compared to negative mothers (763 cases), SARS-CoV-2 infection increased the odds of preterm birth (34 vs 51, 13.8% vs 6.7%, aOR 2.12, 95% CI 1.32-3.36, p = 0.002); iatrogenic preterm delivery was more frequent in infected women (4.9% vs 1.3%, p = 0.001), while the occurrence of spontaneous preterm deliveries was statistically similar (6.1% vs 4.7%). An increased risk of premature rupture of membranes at term (39 vs 75, 15.8% vs 9.8%, aOR 1.70, 95% CI 1.11-2.57, p = 0.013) and neonatal intensive care unit admissions (23 vs 18, 9.3% vs 2.4%, aOR 4.62, 95% CI 2.43-8.94, p <  0.001) was also observed in positive mothers.

CONCLUSION:

This prospective multicentre study demonstrated that pregnant women infected with SARS-CoV-2 have more infection-related obstetric morbidity. This hypothesis merits evaluation of a causal association in further research.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Fetal Membranes, Premature Rupture / Premature Birth / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Female / Humans / Middle aged / Infant, Newborn / Pregnancy / Young adult Country/Region as subject: Europa Language: English Journal: BMC Pregnancy Childbirth Journal subject: Obstetrics Year: 2021 Document Type: Article Affiliation country: S12884-021-03742-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Fetal Membranes, Premature Rupture / Premature Birth / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Female / Humans / Middle aged / Infant, Newborn / Pregnancy / Young adult Country/Region as subject: Europa Language: English Journal: BMC Pregnancy Childbirth Journal subject: Obstetrics Year: 2021 Document Type: Article Affiliation country: S12884-021-03742-4