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The relationship between SARS-COV-2 RNA positive duration and the risk of recurrent positive.
Zhao, Hong; Zhang, Chi; Chen, Xian-Xiang; Zhu, Qi; Huang, Wen-Xiang; Zeng, Yi-Lan; Liu, Ying-Xia; Li, Guo-Jun; Du, Wei-Jun; Yao, Jing; Li, Jia-Wen; Peng, Peng; Wang, Gui-Qiang.
  • Zhao H; Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, Beijing, China.
  • Zhang C; Department of Infectious Disease, Peking University International Hospital, Beijing, China.
  • Chen XX; Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, Beijing, China.
  • Zhu Q; Administrative Office, Wuhan Pulmonary Hospital, Wuhan, China.
  • Huang WX; Department of Tuberculosis, Wuhan Pulmonary Hospital, Wuhan, China.
  • Zeng YL; Department of Infectious Disease, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Liu YX; Administrative Office, Chengdu Public Health Clinical Center, Chengdu, China.
  • Li GJ; Administrative Office, The Third People's Hospital of Shenzhen, Shenzhen, China.
  • Du WJ; Department of Hepatology III, The Third People's Hospital of Shenzhen, Shenzhen, China.
  • Yao J; Department of Internal Medicine, Fankou Branch of Ezhou Central Hospital, Ezhou, China.
  • Li JW; Department of Obstetrics and Gynecology, Fankou Branch of Ezhou Central Hospital, Ezhou, China.
  • Peng P; Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, Beijing, China.
  • Wang GQ; Administrative Office, Wuhan Pulmonary Hospital, Wuhan, China. PengPengwg@126.com.
Infect Dis Poverty ; 10(1): 45, 2021 Mar 31.
Article in English | MEDLINE | ID: covidwho-1166939
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Duration TREATS Hypertensive disease
Subject
Duration
Predicate
TREATS
Object
Hypertensive disease
3. Duration compared_with Duration
Subject
Duration
Predicate
compared_with
Object
Duration
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
5. Duration TREATS Hypertensive disease
Subject
Duration
Predicate
TREATS
Object
Hypertensive disease
6. Duration compared_with Duration
Subject
Duration
Predicate
compared_with
Object
Duration
ABSTRACT

BACKGROUND:

The management of discharge COVID-19 patients with recurrent positive SARS-CoV-2 RNA is challenging. However, there are fewer scientific dissertations about the risk of recurrent positive. The aim of this study was to explore the relationship between SARS-COV-2 RNA positive duration (SPD) and the risk of recurrent positive.

METHODS:

This case-control multi-center study enrolled participants from 8 Chinese hospital including 411 participants (recurrent positive 241). Using unadjusted and multivariate-adjusted logistic regression analyses, generalized additive model with a smooth curve fitting, we evaluated the associations between SPD and risk of recurrent positive. Besides, subgroup analyses were performed to explore the potential interactions.

RESULTS:

Among recurrent positive patients, there were 121 females (50.2%), median age was 50 years old [interquartile range (IQR) 38-63]. In non-adjusted model and adjusted model, SPD was associated with an increased risk of recurrent positive (fully-adjusted model OR = 1.05, 95% CI 1.02-1.08, P = 0.001); the curve fitting was not significant (P = 0.286). Comparing with SPD < 14 days, the risk of recurrent positive in SPD > 28 days was risen substantially (OR = 3.09, 95% CI 1.44-6.63, P = 0.004). Interaction and stratified analyses showed greater effect estimates of SPD and risk of recurrent positive in the hypertension, low monocyte count and percentage patients (P for interaction = 0.008, 0.002, 0.036, respectively).

CONCLUSION:

SPD was associated with a higher risk of recurrent positive and especially SPD > 28 day had a two-fold increase in the relative risk of re-positive as compared with SPD < 14 day. What's more, the risk may be higher among those with hypertension and lower monocyte count or percentage.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Infect Dis Poverty Year: 2021 Document Type: Article Affiliation country: S40249-021-00831-6

Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Infect Dis Poverty Year: 2021 Document Type: Article Affiliation country: S40249-021-00831-6