Your browser doesn't support javascript.
Slow but Evident Recovery from Neocortical Dysfunction and Cognitive Impairment in a Series of Chronic COVID-19 Patients.
Blazhenets, Ganna; Schroeter, Nils; Bormann, Tobias; Thurow, Johannes; Wagner, Dirk; Frings, Lars; Weiller, Cornelius; Meyer, Philipp T; Dressing, Andrea; Hosp, Jonas A.
  • Blazhenets G; Department of Nuclear Medicine, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany; ganna.blazhenets@uniklinik-freiburg.de.
  • Schroeter N; Department of Neurology and Clinical Neuroscience, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
  • Bormann T; Department of Neurology and Clinical Neuroscience, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
  • Thurow J; Department of Nuclear Medicine, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
  • Wagner D; Department of Internal Medicine, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany; and.
  • Frings L; Department of Nuclear Medicine, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
  • Weiller C; Department of Neurology and Clinical Neuroscience, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
  • Meyer PT; Freiburg Brain Imaging Center, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
  • Dressing A; Department of Nuclear Medicine, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
  • Hosp JA; Department of Neurology and Clinical Neuroscience, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
J Nucl Med ; 62(7): 910-915, 2021 07 01.
Article in English | MEDLINE | ID: covidwho-1167265
ABSTRACT
Cognitive impairment is a frequent complaint in coronavirus disease 2019 (COVID-19) and can be related to cortical hypometabolism on 18F-FDG PET at the subacute stage. However, it is unclear if these changes are reversible.

Methods:

We prospectively assessed the Montreal Cognitive Assessment scores and 18F-FDG PET scans of 8 COVID-19 patients at the subacute stage (once no longer infectious) and the chronic stage (˜6 mo after symptom onset). The expression of the previously established COVID-19-related covariance pattern was analyzed at both stages to examine the time course of post-COVID-19 cognitive impairment. For further validation, we also conducted a conventional group analysis.

Results:

Follow-up 18F-FDG PET revealed that there was a significant reduction in the initial frontoparietal and, to a lesser extent, temporal hypometabolism and that this reduction was accompanied by a significant improvement in cognition. The expression of the previously established COVID-19-related pattern was significantly lower at follow-up and correlated inversely with Montreal Cognitive Assessment performance. However, both 18F-FDG PET and cognitive assessment suggest a residual impairment.

Conclusion:

Although a significant recovery of regional neuronal function and cognition can be clearly stated, residuals are still measurable in some patients 6 mo after manifestation of COVID-19. Given the current pandemic situation and tremendous uncertainty concerning the long-term effects of COVID-19, the present study provides novel insights of the highest medical and socioeconomic relevance.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Neocortex / Recovery of Function / Cognitive Dysfunction / COVID-19 Type of study: Cohort study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Nucl Med Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Neocortex / Recovery of Function / Cognitive Dysfunction / COVID-19 Type of study: Cohort study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Nucl Med Year: 2021 Document Type: Article