Treatment of COVID-19: a review of current and prospective pharmacotherapies.

Quek, Eleanor; Tahir, Hasan; Kumar, Poornima; Hastings, Robert; Jha, Rajeev

Quek, Eleanor; Tahir, Hasan; Kumar, Poornima; Hastings, Robert; Jha, Rajeev.

Quek E; Department of General Medicine, Barnet Hospital, Royal Free London NHS Foundation Trust, London, UK.
Tahir H; Department of Rheumatology and General Medicine, Barnet Hospital, Royal Free London NHS Foundation Trust, London, UK.
Kumar P; Division of Medicine, University College London, London, UK.
Hastings R; Department of Clinical Haematology, Barnet Hospital, Royal Free London NHS Foundation Trust, London, UK.
Jha R; Department of Respiratory Medicine, Barnet Hospital, Royal Free London NHS Foundation Trust, London, UK.

Br J Hosp Med (Lond) ; 82(3): 1-9, 2021 Mar 02.

Article in English | MEDLINE | ID: covidwho-1168180

ABSTRACT

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread and have grave health and socioeconomic consequences worldwide. Researchers have raced to understand the pathophysiological mechanisms underpinning the disease caused by SARS-CoV-2 so that effective therapeutic targets can be discovered. This review summarises the key pharmacotherapies that are being investigated for treatment of COVID-19, including antiviral, immunomodulator and anticoagulation strategies.

Subject(s)

Anticoagulants/therapeutic use; Antiviral Agents/therapeutic use; COVID-19 Drug Treatment; Glucocorticoids/therapeutic use; Immunologic Factors/therapeutic use; Platelet Aggregation Inhibitors/therapeutic use; Adenosine Monophosphate/analogs & derivatives; Adenosine Monophosphate/therapeutic use; Alanine/analogs & derivatives; Alanine/therapeutic use; Antibodies, Monoclonal, Humanized/therapeutic use; Azetidines/therapeutic use; COVID-19/therapy; Colchicine/therapeutic use; Dexamethasone/therapeutic use; Humans; Immunization, Passive; Ivermectin/therapeutic use; Janus Kinase Inhibitors/therapeutic use; Purines/therapeutic use; Pyrazoles/therapeutic use; SARS-CoV-2; Sulfonamides/therapeutic use; COVID-19 Serotherapy

Keywords

Anticoagulation; Antivirals; COVID-19; Immunomodulator

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Platelet Aggregation Inhibitors / COVID-19 Drug Treatment / Glucocorticoids / Immunologic Factors / Anticoagulants Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Br J Hosp Med (Lond) Journal subject: Hospitals / Medicine Year: 2021 Document Type: Article Affiliation country: Hmed.2021.0112

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