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Topical preparations to reduce SARS-CoV-2 aerosolization in head and neck mucosal surgery.
Parhar, Harman S; Tasche, Kendall; Brody, Robert M; Weinstein, Gregory S; O'Malley, Bert W; Shanti, Rabie M; Newman, Jason G.
  • Parhar HS; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Tasche K; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Brody RM; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Weinstein GS; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • O'Malley BW; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Shanti RM; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Newman JG; Department of Oral and Maxillofacial Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Head Neck ; 42(6): 1268-1272, 2020 06.
Article in English | MEDLINE | ID: covidwho-116903
ABSTRACT

AIM:

The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has put health care workers at risk when exposed to aerosolized viral particles during upper airway mucosal surgery. The objective of this review was to discuss topical preparations that could be utilized preoperatively to help to decrease viral load and potentially reduce the risks of viral transmission.

METHODS:

A PubMed/MEDLINE database review of articles was performed querying topical preparations with virucidal activity against coronaviruses.

RESULTS:

Povidone-iodine (PVP-I) solutions ranging from 0.23% to 7% have been found to demonstrate highly effective virucidal activity against a broad range of viruses including several coronaviruses responsible for recent epidemics including SARS-CoV-1 and MERS-CoV.

CONCLUSIONS:

While specific evidence regarding SARS-CoV-2 is lacking, PVP-I-based preparations have been successfully demonstrated to reduce viral loads of coronaviruses. They are relatively safe to use in the upper airway and may reduce risk of SARS-CoV-2 aerosolization during upper airway mucosal surgery.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Otolaryngology / Pneumonia, Viral / Infectious Disease Transmission, Patient-to-Professional / Coronavirus Infections / Pandemics / Betacoronavirus / Anti-Infective Agents, Local Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: Head Neck Journal subject: Neoplasms Year: 2020 Document Type: Article Affiliation country: Hed.26200

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Otolaryngology / Pneumonia, Viral / Infectious Disease Transmission, Patient-to-Professional / Coronavirus Infections / Pandemics / Betacoronavirus / Anti-Infective Agents, Local Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: Head Neck Journal subject: Neoplasms Year: 2020 Document Type: Article Affiliation country: Hed.26200