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Clinical features and predictors of severity in COVID-19 patients with critical illness in Singapore.
Puah, Ser Hon; Young, Barnaby Edward; Chia, Po Ying; Ho, Vui Kian; Loh, Jiashen; Gokhale, Roshni Sadashiv; Tan, Seow Yen; Sewa, Duu Wen; Kalimuddin, Shirin; Tan, Chee Keat; Pada, Surinder K M S; Cove, Matthew Edward; Chai, Louis Yi Ann; Parthasarathy, Purnima; Ho, Benjamin Choon Heng; Ng, Jensen Jiansheng; Ling, Li Min; Abisheganaden, John A; Lee, Vernon J M; Tan, Cher Heng; Lin, Raymond T P; Leo, Yee Sin; Lye, David C; Yeo, Tsin Wen.
  • Puah SH; Tan Tock Seng Hospital, Singapore, Singapore.
  • Young BE; Tan Tock Seng Hospital, Singapore, Singapore.
  • Chia PY; National Centre for Infectious Diseases, Singapore, Singapore.
  • Ho VK; Lee Kong Chian School of Medicine, Novena Campus Clinical Sciences Building, 11 Mandalay Rd, Singapore, 308232, Singapore.
  • Loh J; Tan Tock Seng Hospital, Singapore, Singapore.
  • Gokhale RS; National Centre for Infectious Diseases, Singapore, Singapore.
  • Tan SY; Lee Kong Chian School of Medicine, Novena Campus Clinical Sciences Building, 11 Mandalay Rd, Singapore, 308232, Singapore.
  • Sewa DW; Sengkang General Hospital, Singapore, Singapore.
  • Kalimuddin S; Sengkang General Hospital, Singapore, Singapore.
  • Tan CK; Changi General Hospital, Singapore, Singapore.
  • Pada SKMS; Singapore General Hospital, Singapore, Singapore.
  • Cove ME; Singapore General Hospital, Singapore, Singapore.
  • Chai LYA; Singapore General Hospital, Singapore, Singapore.
  • Parthasarathy P; Duke-NUS Medical School, Singapore, Singapore.
  • Ho BCH; Ng Teng Fong General Hospital, Singapore, Singapore.
  • Ng JJ; Ng Teng Fong General Hospital, Singapore, Singapore.
  • Ling LM; Yong Loo Lin School of Medicine, Singapore, Singapore.
  • Abisheganaden JA; National University Hospital, Singapore, Singapore.
  • Lee VJM; Yong Loo Lin School of Medicine, Singapore, Singapore.
  • Tan CH; National University Hospital, Singapore, Singapore.
  • Lin RTP; Yong Loo Lin School of Medicine, Singapore, Singapore.
  • Leo YS; Khoo Teck Puat Hospital, Singapore, Singapore.
  • Lye DC; Tan Tock Seng Hospital, Singapore, Singapore.
  • Yeo TW; Tan Tock Seng Hospital, Singapore, Singapore.
Sci Rep ; 11(1): 7477, 2021 04 05.
Article in English | MEDLINE | ID: covidwho-1169408
ABSTRACT
We aim to describe a case series of critically and non-critically ill COVID-19 patients in Singapore. This was a multicentered prospective study with clinical and laboratory details. Details for fifty uncomplicated COVID-19 patients and ten who required mechanical ventilation were collected. We compared clinical features between the groups, assessed predictors of intubation, and described ventilatory management in ICU patients. Ventilated patients were significantly older, reported more dyspnea, had elevated C-reactive protein and lactate dehydrogenase. A multivariable logistic regression model identified respiratory rate (aOR 2.83, 95% CI 1.24-6.47) and neutrophil count (aOR 2.39, 95% CI 1.34-4.26) on admission as independent predictors of intubation with area under receiver operating characteristic curve of 0.928 (95% CI 0.828-0.979). Median APACHE II score was 19 (IQR 17-22) and PaO2/FiO2 ratio before intubation was 104 (IQR 89-129). Median peak FiO2 was 0.75 (IQR 0.6-1.0), positive end-expiratory pressure 12 (IQR 10-14) and plateau pressure 22 (IQR 18-26) in the first 24 h of ventilation. Median duration of ventilation was 6.5 days (IQR 5.5-13). There were no fatalities. Most COVID-19 patients in Singapore who required mechanical ventilation because of ARDS were extubated with no mortality.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-81377-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-81377-3