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Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 Patients.
Caracciolo, Massimo; Correale, Pierpaolo; Mangano, Carmelo; Foti, Giuseppe; Falcone, Carmela; Macheda, Sebastiano; Cuzzola, Maria; Conte, Marco; Falzea, Antonella Consuelo; Iuliano, Eleonora; Morabito, Antonella; Caraglia, Michele; Polimeni, Nicola; Ferrarelli, Anna; Labate, Demetrio; Tescione, Marco; Di Renzo, Laura; Chiricolo, Gaetano; Romano, Lorenzo; De Lorenzo, Antonino.
  • Caracciolo M; Unit of Post-Surgery Intensive Therapy (USDO), Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Correale P; Medical Oncology Unit, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Mangano C; Unit of Infectious Disease, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Foti G; Unit of Infectious Disease, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Falcone C; Unit of Radiology, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Macheda S; Unit of Intensive Care Medicine and Anaesthesia, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Cuzzola M; Microbiology Unit, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Conte M; Microbiology Unit, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Falzea AC; Medical Oncology Unit, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Iuliano E; Medical Oncology Unit, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Morabito A; Unit of Pharmacy, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Caraglia M; Department of Precision Medicine, University of Campania "L. Vanvitelli", Naples, Italy.
  • Polimeni N; Biogem Scarl, Institute of Genetic Research, Laboratory of Precision and Molecular Oncology, Ariano Irpino, Italy.
  • Ferrarelli A; Unit of Intensive Care Medicine and Anaesthesia, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Labate D; Unit of Radiology, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Tescione M; Unit of Intensive Care Medicine and Anaesthesia, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Di Renzo L; Unit of Intensive Care Medicine and Anaesthesia, Grand Metropolitan Hospital, Reggio Calabria, Italy.
  • Chiricolo G; Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
  • Romano L; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
  • De Lorenzo A; PhD School of Applied Medical, Surgical Sciences, University of Rome Tor Vergata, Rome, Italy.
Front Immunol ; 12: 613070, 2021.
Article in English | MEDLINE | ID: covidwho-1170085
ABSTRACT
Lack of specific antiviral treatment for COVID-19 has resulted in long hospitalizations and high mortality rate. By harnessing the regulatory effects of adenosine on inflammatory mediators, we have instituted a new therapeutic treatment with inhaled adenosine in COVID-19 patients, with the aim of reducing inflammation, the onset of cytokine storm, and therefore to improve prognosis. The use of inhaled adenosine in COVID19 patients has allowed reduction of length of stay, on average 6 days. This result is strengthened by the decrease in SARS-CoV-2 positive days. In treated patients compared to control, a clear improvement in PaO2/FiO2 was observed together with a reduction in inflammation parameters, such as the decrease of CRP level. Furthermore, the efficacy of inhaled exogenous adenosine led to an improvement of the prognosis indices, NLR and PLR. The treatment seems to be safe and modulates the immune system, allowing an effective response against the viral infection progression, reducing length of stay and inflammation parameters.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adenosine / COVID-19 Drug Treatment Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.613070

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adenosine / COVID-19 Drug Treatment Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.613070