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Consistency of the results of rapid serological tests for SARS-CoV-2 among healthcare workers in a large national hospital in Tokyo, Japan.
Yamamoto, Shohei; Tanaka, Akihito; Kobayashi, Shinji; Oshiro, Yusuke; Ozeki, Mitsuru; Maeda, Kenji; Matsuda, Kouki; Miyo, Kengo; Mizoue, Tetsuya; Sugiura, Wataru; Mitsuya, Hiroaki; Sugiyama, Haruhito; Ohmagari, Norio.
  • Yamamoto S; Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
  • Tanaka A; Department of Rehabilitation Sciences, Kitasato University Graduate School of Medical Sciences, Kanagawa, Japan.
  • Kobayashi S; Department of Laboratory Testing, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
  • Oshiro Y; Department of Laboratory Testing, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
  • Ozeki M; Department of Laboratory Testing, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
  • Maeda K; Department of Laboratory Testing, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
  • Matsuda K; Department of Refractory Viral Infection, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
  • Miyo K; Department of Refractory Viral Infection, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
  • Mizoue T; Center of Medical Informatics Intelligence, National Center for Global Health and Medicine, Tokyo, Japan.
  • Sugiura W; Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
  • Mitsuya H; Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
  • Sugiyama H; Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
  • Ohmagari N; Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Glob Health Med ; 3(2): 90-94, 2021 Apr 30.
Article in English | MEDLINE | ID: covidwho-1170608
ABSTRACT
We assessed the consistency of seropositive results of three rapid immunoassays (Kits A, B, and C) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared to highly accurate serological tests (Abbott and Roche) among healthcare workers in a hospital in Tokyo. The seroprevalence of SARS-CoV-2 immunoglobulin G was 0.41%, 2.36%, and 0.08% using Kits A, B, and C, respectively. Of the 51 samples that were seropositive on any rapid test, all were seronegative on both the Abbott and the Roche assays. Given that the seroprevalence of SARS-CoV-2 immunoglobulin G varied widely according to the choice of rapid test and the rapid test results were inconsistent with the results of highly accurate tests, the diagnostic accuracy of rapid serological tests for SARS-CoV-2 should be assessed before introducing these tests for point-of-care testing or surveillance.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Observational study Language: English Journal: Glob Health Med Year: 2021 Document Type: Article Affiliation country: Ghm.2021.01022

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Observational study Language: English Journal: Glob Health Med Year: 2021 Document Type: Article Affiliation country: Ghm.2021.01022