Your browser doesn't support javascript.
Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke.
Patel, Urvish; Malik, Preeti; Mehta, Deep; Rajput, Priyanka; Shrivastava, Mashu; Naveed, Madiha; Urhoghide, Eseosa; Martin, Mehwish; Somi, Shamima; Jaiswal, Richa; Patel, Achint; Israni, Avantika; Singh, Jagmeet; Kichloo, Asim; Shah, Shamik; Lunagariya, Abhishek.
  • Patel U; Department of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Malik P; Department of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: pmalik.ma@gmail.com.
  • Mehta D; Clinical Research Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Rajput P; Department of Family Medicine, Jackson Park Hospital and Medical Center, Chicago, IL, USA.
  • Shrivastava M; Department of Internal Medicine, Kansas university medical center, Kansas City, KS, USA.
  • Naveed M; siParadigm Diagnostic Informatics, Pine Brook, NJ, USA.
  • Urhoghide E; Department of Internal Medicine, Hudson Regional Hospital, Secaucus, NJ, USA.
  • Martin M; Department of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Somi S; Department of Internal Medicine, Grand Rehabilitation and Nursing Home, Great Neck, NY, USA.
  • Jaiswal R; Department of Internal Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Patel A; Department of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Israni A; Department of Internal Medicine, St Mary Medical Center, Langhorne, PA, USA.
  • Singh J; Department of Internal Medicine, Geisinger Commonwealth School of Medicine, Scranton, PA, USA.
  • Kichloo A; Department of Internal Medicine, Central Michigan University, College of Medicine, Saginaw, MI, USA; USA & Department of Internal Medicine, Samaritan Medical Center, Watertown, NY, USA.
  • Shah S; Department of Neurology, Stormont Vail Health, Topeka, KS, USA.
  • Lunagariya A; Department of Neurology, University of Central Florida - HCA Consortium Neurology, Orlando, Florida, USA.
J Stroke Cerebrovasc Dis ; 30(7): 105805, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1171128
Semantic information from SemMedBD (by NLM)
1. Complication CAUSES Cerebrovascular accident
Subject
Complication
Predicate
CAUSES
Object
Cerebrovascular accident
2. Thromboembolism CAUSES Cerebrovascular accident
Subject
Thromboembolism
Predicate
CAUSES
Object
Cerebrovascular accident
3. Cardiac complication CAUSES Cerebrovascular accident
Subject
Cardiac complication
Predicate
CAUSES
Object
Cerebrovascular accident
4. Secondary Infections CAUSES Cerebrovascular accident
Subject
Secondary Infections
Predicate
CAUSES
Object
Cerebrovascular accident
5. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. Septic Shock PROCESS_OF Patients
Subject
Septic Shock
Predicate
PROCESS_OF
Object
Patients
8. Complication PROCESS_OF Patients
Subject
Complication
Predicate
PROCESS_OF
Object
Patients
9. Cerebrovascular accident PROCESS_OF Patients
Subject
Cerebrovascular accident
Predicate
PROCESS_OF
Object
Patients
10. Complication CAUSES Cerebrovascular accident
Subject
Complication
Predicate
CAUSES
Object
Cerebrovascular accident
11. Thromboembolism CAUSES Cerebrovascular accident
Subject
Thromboembolism
Predicate
CAUSES
Object
Cerebrovascular accident
12. Cardiac complication CAUSES Cerebrovascular accident
Subject
Cardiac complication
Predicate
CAUSES
Object
Cerebrovascular accident
13. Secondary Infections CAUSES Cerebrovascular accident
Subject
Secondary Infections
Predicate
CAUSES
Object
Cerebrovascular accident
14. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
15. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
16. Septic Shock PROCESS_OF Patients
Subject
Septic Shock
Predicate
PROCESS_OF
Object
Patients
17. Complication PROCESS_OF Patients
Subject
Complication
Predicate
PROCESS_OF
Object
Patients
18. Cerebrovascular accident PROCESS_OF Patients
Subject
Cerebrovascular accident
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

INTRODUCTION:

There is limited literature on coronavirus disease 2019 (COVID -19) complications such as thromboembolism, cardiac complications etc. as possible trigger for stroke. Hence, we aim to evaluate the prevalence and outcomes of COVID-19 related cardiovascular complications and secondary infection and their possibility as potential triggers for the stroke.

METHODS:

Data from observational studies describing the complications [acute cardiac injury (ACI), cardiac arrhythmias (CA), disseminated intravascular coagulation (DIC), septic shock, secondary infection] and outcomes of COVID-19 hospitalized patients from December 1, 2019 to June 30, 2020, were extracted following PRISMA guidelines. Adverse outcomes defined as intensive care units, oxygen saturation less than 90%, invasive mechanical ventilation, severe disease, and in-hospital mortality. The odds ratio and 95% confidence interval were obtained, and forest plots were created using random-effects models. A short review of these complications as triggers of stroke was conducted.

RESULTS:

16 studies with 3480 confirmed COVID-19 patients, prevalence of ACI [38%vs5.9%], CA [26%vs5.3%], DIC [4%vs0.74%], septic shock [18%vs0.36%], and infection [30%vs12.5%] was higher among patients with poor outcomes. In meta-analysis, ACI [aOR9.93(95%CI3.95-25.00], CA [7.52(3.29-17.18)], DIC [7.36(1.24-43.73)], septic shock [30.12(7.56-120.10)], and infection [10.41(4.47-24.27)] had higher odds of adverse outcomes. Patients hospitalized with acute ischemic stroke and intracerebral hemorrhage, had complications like pulmonary embolism, venous thromboembolism, DIC, etc. and had poor outcomes

CONCLUSION:

The complications like acute cardiac injury, cardiac arrhythmias, DIC, septic shock, and secondary infection had poor outcomes. Patients with stroke were having history of these complications. Long term monitoring is required in such patients to prevent stroke and mitigate adverse outcomes.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Arrhythmias, Cardiac / Disseminated Intravascular Coagulation / Venous Thromboembolism / Ischemic Stroke / COVID-19 Type of study: Diagnostic study / Etiology study / Prevalence study / Prognostic study / Randomized controlled trials / Reviews / Risk factors / Systematic review Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Stroke Cerebrovasc Dis Journal subject: Vascular Diseases / Brain Year: 2021 Document Type: Article Affiliation country: J.jstrokecerebrovasdis.2021.105805

Full text: Available Collection: International databases Database: MEDLINE Main subject: Arrhythmias, Cardiac / Disseminated Intravascular Coagulation / Venous Thromboembolism / Ischemic Stroke / COVID-19 Type of study: Diagnostic study / Etiology study / Prevalence study / Prognostic study / Randomized controlled trials / Reviews / Risk factors / Systematic review Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Stroke Cerebrovasc Dis Journal subject: Vascular Diseases / Brain Year: 2021 Document Type: Article Affiliation country: J.jstrokecerebrovasdis.2021.105805