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Ocular Assessments of a Series of Newborns Gestationally Exposed to Maternal COVID-19 Infection.
Kiappe, Olívia Pereira; Santos da Cruz, Natasha Ferreira; Rosa, Paulo Alberto Cervi; Arrais, Luciana; Bueno de Moraes, Nilva Simeren.
  • Kiappe OP; Federal University of Sao Paulo, Escola Paulista de Medicina, São Paulo, Brazil.
  • Santos da Cruz NF; Federal University of Sao Paulo, Escola Paulista de Medicina, São Paulo, Brazil.
  • Rosa PAC; Federal University of Sao Paulo, Escola Paulista de Medicina, São Paulo, Brazil.
  • Arrais L; Federal University of Sao Paulo, Escola Paulista de Medicina, São Paulo, Brazil.
  • Bueno de Moraes NS; Federal University of Sao Paulo, Escola Paulista de Medicina, São Paulo, Brazil.
JAMA Ophthalmol ; 139(7): 777-780, 2021 Jul 01.
Article in English | MEDLINE | ID: covidwho-1171509
ABSTRACT
IMPORTANCE Congenital viral infections leading to ocular abnormalities are frequent and devastating. As ophthalmological manifestations of COVID-19 in newborns are still unknown, it is important to clarify if SARS-CoV-2 could be associated with ocular abnormalities.

OBJECTIVE:

To determine whether exposure to SARS-CoV-2 is associated with outcomes in the eyes of newborns. DESIGN, SETTING, AND

PARTICIPANTS:

This case series enrolled newborns from April to November 2020 from 3 different maternity hospitals in São Paulo, Brazil. The diagnosis of COVID-19 in mothers and newborns was based on real-time reverse transcriptase-polymerase chain reaction assays with material obtained from oronasopharyngeal swab sample; positive IGM serology was also considered as a diagnostic test for mothers. Newborns were excluded if they had any evidence of another congenital infection. All infants underwent external ocular examination and binocular indirect ophthalmoscopy. EXPOSURES Serology test for COVID-19 and detection of SARS-CoV-2 from oronasopharyngeal specimen using a real-time reverse transcriptase-polymerase chain reaction assay on both mothers and newborns. MAIN OUTCOMES AND

MEASURES:

Screening for ophthalmologic manifestation in newborns after maternal COVID-19 infection.

RESULTS:

A total of 165 newborns (age range at examination, 1 to 18 days) were evaluated. Of these, 123 (74.5%) were born at full term, and 42 (25.4%) were born preterm. Maternal gestational age at the time of COVID-19-positive test varied from first to 40th gestational weeks. Six newborns (3.6%) had positive polymerase chain reaction findings for SARS-CoV-2. One newborn tested positive within 18 days (horizontal transmission), and 5 newborns tested positive in the first day of life (possible vertical transmission). None had ocular abnormalities. Concerning exposed newborns with negative test results, 1 presented with venous engorgement and vascular tortuosity, 7 had intraretinal hemorrhages, and 2 were diagnosed as having retinopathy of prematurity. CONCLUSIONS AND RELEVANCE In this uncontrolled case series of Brazilian newborns of mothers with COVID-19 infection, a low rate of COVID-19 infection was found among newborns, and none had ocular abnormalities. Additional controlled studies may be warranted to confirm these findings.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Prenatal Exposure Delayed Effects / Eye Infections, Viral / Infectious Disease Transmission, Vertical / Eye / COVID-19 Type of study: Diagnostic study / Experimental Studies Topics: Long Covid Limits: Female / Humans / Male / Infant, Newborn / Pregnancy Country/Region as subject: South America / Brazil Language: English Journal: JAMA Ophthalmol Year: 2021 Document Type: Article Affiliation country: Jamaophthalmol.2021.1088

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Prenatal Exposure Delayed Effects / Eye Infections, Viral / Infectious Disease Transmission, Vertical / Eye / COVID-19 Type of study: Diagnostic study / Experimental Studies Topics: Long Covid Limits: Female / Humans / Male / Infant, Newborn / Pregnancy Country/Region as subject: South America / Brazil Language: English Journal: JAMA Ophthalmol Year: 2021 Document Type: Article Affiliation country: Jamaophthalmol.2021.1088