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Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality.
Alghamdi, Jahad; Alaamery, Manal; Barhoumi, Tlili; Rashid, Mamoon; Alajmi, Hala; Aljasser, Nasser; Alhendi, Yaseen; Alkhalaf, Hind; Alqahtani, Hanadi; Algablan, Omer; Alshaya, Abdulraham I; Tashkandi, Nabiha; Massadeh, Salam; Almuzzaini, Bader; Ehaideb, Salleh N; Bosaeed, Mohammad; Ayoub, Kamal; Yezli, Saber; Khan, Anas; Alaskar, Ahmed; Bouchama, Abderrezak.
  • Alghamdi J; Saudi Biobank, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: alghamdija@ngha.med.sa.
  • Alaamery M; Developmental Medicine Department, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard- Health Affairs, Riyadh, Saudi Arabia; KACST-BWH Centre of Excellence for Biomedicine, Joint Centers
  • Barhoumi T; Core Facility and Research Platforms, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
  • Rashid M; Department of Bioinformatics, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
  • Alajmi H; Saudi Biobank, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
  • Aljasser N; Saudi Biobank, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
  • Alhendi Y; Saudi Biobank, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
  • Alkhalaf H; Saudi Biobank, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
  • Alqahtani H; Saudi Biobank, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
  • Algablan O; Saudi Biobank, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
  • Alshaya AI; College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
  • Tashkandi N; Nursing Services, Ministry of the National Guard - Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
  • Massadeh S; Developmental Medicine Department, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard- Health Affairs, Riyadh, Saudi Arabia; KACST-BWH Centre of Excellence for Biomedicine, Joint Centers
  • Almuzzaini B; Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
  • Ehaideb SN; Experimental Medicine Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
  • Bosaeed M; Department of Medicine, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
  • Ayoub K; King Abdulaziz Cardiac Center, Ministry of the National Guard - Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
  • Yezli S; The Global Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia.
  • Khan A; The Global Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia; College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Alaskar A; Oncology Department, Ministry of the National Guard - Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
  • Bouchama A; Experimental Medicine Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: bouchamaab@ngha.med.sa.
Genomics ; 113(4): 1733-1741, 2021 07.
Article in English | MEDLINE | ID: covidwho-1171554
Semantic information from SemMedBD (by NLM)
1. Interferons STIMULATES B3GNT3 gene|B3GNT3
Subject
Interferons
Predicate
STIMULATES
Object
B3GNT3 gene|B3GNT3
2. Interferons STIMULATES Membrane Proteins
Subject
Interferons
Predicate
STIMULATES
Object
Membrane Proteins
3. Gene Mutant PREDISPOSES Severe viral infection
Subject
Gene Mutant
Predicate
PREDISPOSES
Object
Severe viral infection
4. Patients LOCATION_OF Alleles
Subject
Patients
Predicate
LOCATION_OF
Object
Alleles
5. AA genotype PROCESS_OF Patients
Subject
AA genotype
Predicate
PROCESS_OF
Object
Patients
6. Interferons STIMULATES B3GNT3 gene|B3GNT3
Subject
Interferons
Predicate
STIMULATES
Object
B3GNT3 gene|B3GNT3
7. Interferons STIMULATES Membrane Proteins
Subject
Interferons
Predicate
STIMULATES
Object
Membrane Proteins
8. Gene Mutant PREDISPOSES Severe viral infection
Subject
Gene Mutant
Predicate
PREDISPOSES
Object
Severe viral infection
9. Patients LOCATION_OF Alleles
Subject
Patients
Predicate
LOCATION_OF
Object
Alleles
10. AA genotype PROCESS_OF Patients
Subject
AA genotype
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population. We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01-2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16-4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA-Binding Proteins / Genetic Predisposition to Disease / SARS-CoV-2 / COVID-19 / Membrane Proteins Type of study: Prognostic study / Risk factors Topics: Variants Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Genomics Journal subject: Genetics Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA-Binding Proteins / Genetic Predisposition to Disease / SARS-CoV-2 / COVID-19 / Membrane Proteins Type of study: Prognostic study / Risk factors Topics: Variants Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Genomics Journal subject: Genetics Year: 2021 Document Type: Article