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Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery process.
Zheng, Hong; Jin, Shengwei; Li, Ting; Ying, Weiyang; Ying, Binyu; Chen, Dong; Ning, Jie; Zheng, Chanfan; Li, Yuping; Li, Chen; Chen, Chengshui; Li, Xiaokun; Gao, Hongchang.
  • Zheng H; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, China.
  • Jin S; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
  • Li T; Department of Anesthesia and Critical Care, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
  • Ying W; Clinical Research Unit, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
  • Ying B; Department of Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
  • Chen D; Department of Critical Care Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
  • Ning J; Wenzhou Central Hospital, Wenzhou 325015, China.
  • Zheng C; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
  • Li Y; Clinical Research Unit, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
  • Li C; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, China.
  • Chen C; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
  • Li X; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, China.
  • Gao H; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Comput Struct Biotechnol J ; 19: 1863-1873, 2021.
Article in English | MEDLINE | ID: covidwho-1171610
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. COVID-19 PROCESS_OF Male population group
Subject
COVID-19
Predicate
PROCESS_OF
Object
Male population group
3. COVID-19 PROCESS_OF Woman
Subject
COVID-19
Predicate
PROCESS_OF
Object
Woman
4. Male population group LOCATION_OF Plasma
Subject
Male population group
Predicate
LOCATION_OF
Object
Plasma
5. Woman LOCATION_OF Plasma
Subject
Woman
Predicate
LOCATION_OF
Object
Plasma
6. Plasma PART_OF Patients
Subject
Plasma
Predicate
PART_OF
Object
Patients
7. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
8. COVID-19 PROCESS_OF Male population group
Subject
COVID-19
Predicate
PROCESS_OF
Object
Male population group
9. COVID-19 PROCESS_OF Woman
Subject
COVID-19
Predicate
PROCESS_OF
Object
Woman
10. Male population group LOCATION_OF Plasma
Subject
Male population group
Predicate
LOCATION_OF
Object
Plasma
11. Woman LOCATION_OF Plasma
Subject
Woman
Predicate
LOCATION_OF
Object
Plasma
12. Plasma PART_OF Patients
Subject
Plasma
Predicate
PART_OF
Object
Patients
ABSTRACT
Metabolic profiling in COVID-19 patients has been associated with disease severity, but there is no report on sex-specific metabolic changes in discharged survivors. Herein we used an integrated approach of LC-MS-and GC-MS-based untargeted metabolomics to analyze plasma metabolic characteristics in men and women with non-severe COVID-19 at both acute period and 30 days after discharge. The results demonstrate that metabolic alterations in plasma of COVID-19 patients during the recovery and rehabilitation process were presented in a sex specific manner. Overall, the levels of most metabolites were increased in COVID-19 patients after the cure relative to acute period. The major plasma metabolic changes were identified including fatty acids in men and glycerophosphocholines and carbohydrates in women. In addition, we found that women had shorter length of hospitalization than men and metabolic characteristics may contribute to predict the duration from positive to negative in non-severe COVID-19 patients. Collectively, this study shed light on sex-specific metabolic shifts in non-severe COVID-19 patients during the recovery process, suggesting a sex bias in prognostic and therapeutic evaluations based on metabolic profiling.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Risk factors Language: English Journal: Comput Struct Biotechnol J Year: 2021 Document Type: Article Affiliation country: J.csbj.2021.03.039

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Risk factors Language: English Journal: Comput Struct Biotechnol J Year: 2021 Document Type: Article Affiliation country: J.csbj.2021.03.039