Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery process.
Comput Struct Biotechnol J
; 19: 1863-1873, 2021.
Article
in English
| MEDLINE | ID: covidwho-1171610
ABSTRACT
Metabolic profiling in COVID-19 patients has been associated with disease severity, but there is no report on sex-specific metabolic changes in discharged survivors. Herein we used an integrated approach of LC-MS-and GC-MS-based untargeted metabolomics to analyze plasma metabolic characteristics in men and women with non-severe COVID-19 at both acute period and 30 days after discharge. The results demonstrate that metabolic alterations in plasma of COVID-19 patients during the recovery and rehabilitation process were presented in a sex specific manner. Overall, the levels of most metabolites were increased in COVID-19 patients after the cure relative to acute period. The major plasma metabolic changes were identified including fatty acids in men and glycerophosphocholines and carbohydrates in women. In addition, we found that women had shorter length of hospitalization than men and metabolic characteristics may contribute to predict the duration from positive to negative in non-severe COVID-19 patients. Collectively, this study shed light on sex-specific metabolic shifts in non-severe COVID-19 patients during the recovery process, suggesting a sex bias in prognostic and therapeutic evaluations based on metabolic profiling.
ALT, Alanine aminotransferase; AP, Acute period (AP); APTT, Activated partial thromboplastin time; BCAAs, Branchedchain amino acids; BP, Blood platelet; CA, Carbamide; COVID-19; COVID-19, Novel coronavirus disease 2019; CRP, C-reactive protein; DAA, Dehydroascorbic acid; DD, D-dimer; DP, Diastolic pressure; FIB, Fibrinogen; FP, Follow-up period; Fatty acid; GPCs, Glycerophosphocholines; HGB, Hemoglobin; LY, Lymphocyte; Metabolism; NG, Neutrophilic granulocyte; NK, Natural killer; PCT, Procalcitonin; PLS-DA, Partial least squares-discriminant analysis; PLSR, Partial least squares regression; PT, Prothrombin time; PTC, Phosphatidylcholine; RDW, Red cell distribution width; RR, Respiratory rate; S1P, Sphingosine-1-phosphate; SARS-CoV; Sex difference; TBL, Total B lymphocyte; TTL, Total T lymphocyte; WBC, White blood cell
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Prognostic study
Language:
English
Journal:
Comput Struct Biotechnol J
Year:
2021
Document Type:
Article
Affiliation country:
J.csbj.2021.03.039
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