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Discovery and development of safe-in-man broad-spectrum antiviral agents.
Andersen, Petter I; Ianevski, Aleksandr; Lysvand, Hilde; Vitkauskiene, Astra; Oksenych, Valentyn; Bjørås, Magnar; Telling, Kaidi; Lutsar, Irja; Dumpis, Uga; Irie, Yasuhiko; Tenson, Tanel; Kantele, Anu; Kainov, Denis E.
  • Andersen PI; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7028 Trondheim, Norway.
  • Ianevski A; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7028 Trondheim, Norway.
  • Lysvand H; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7028 Trondheim, Norway.
  • Vitkauskiene A; Department of Laboratory Medicine, Lithuanian University of Health Science, 44307 Kaunas, Lithuania.
  • Oksenych V; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7028 Trondheim, Norway.
  • Bjørås M; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7028 Trondheim, Norway.
  • Telling K; Institute of Technology, University of Tartu, 50090 Tartu, Estonia.
  • Lutsar I; Institute of Medical Microbiology, University of Tartu, Tartu 50411, Estonia.
  • Dumpis U; Latvian Biomedical Research and Study Centre, Riga 1067, Latvia.
  • Irie Y; Institute of Technology, University of Tartu, 50090 Tartu, Estonia.
  • Tenson T; Institute of Technology, University of Tartu, 50090 Tartu, Estonia.
  • Kantele A; Helsinki University Hospital (HUS) and University of Helsinki, Helsinki 00290, Finland.
  • Kainov DE; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7028 Trondheim, Norway; Institute of Technology, University of Tartu, 50090 Tartu, Estonia; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, 00014 Helsinki, Finland. Electroni
Int J Infect Dis ; 93: 268-276, 2020 Apr.
Article in English | MEDLINE | ID: covidwho-1172
Semantic information from SemMedBD (by NLM)
1. Virus Diseases PROCESS_OF World
Subject
Virus Diseases
Predicate
PROCESS_OF
Object
World
2. Antiviral Agents TREATS Virus Diseases
Subject
Antiviral Agents
Predicate
TREATS
Object
Virus Diseases
3. Viral Vaccines TREATS Virus Diseases
Subject
Viral Vaccines
Predicate
TREATS
Object
Virus Diseases
4. Virus Diseases PROCESS_OF World
Subject
Virus Diseases
Predicate
PROCESS_OF
Object
World
5. Antiviral Agents TREATS Virus Diseases
Subject
Antiviral Agents
Predicate
TREATS
Object
Virus Diseases
6. Viral Vaccines TREATS Virus Diseases
Subject
Viral Vaccines
Predicate
TREATS
Object
Virus Diseases
ABSTRACT
Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs, i.e. compounds targeting viruses belonging to two or more viral families) could provide additional protection of the general population from emerging and re-emerging viral diseases, reinforcing the arsenal of available antiviral options. Here, we review discovery and development of BSAAs and summarize the information on 120 safe-in-man agents in a freely accessible database (https//drugvirus.info/). Future and ongoing pre-clinical and clinical studies will increase the number of BSAAs, expand the spectrum of their indications, and identify drug combinations for treatment of emerging and re-emerging viral infections as well as co-infections.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Drug Discovery / Drug Development Topics: Vaccines Limits: Animals / Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: J.ijid.2020.02.018

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Drug Discovery / Drug Development Topics: Vaccines Limits: Animals / Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: J.ijid.2020.02.018