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SARS-CoV-2: The Road Less Traveled-From the Respiratory Mucosa to the Brain.
Arunachalam, Jayamuruga Pandian; U R, Anoop; Verma, Kavita; Rajendran, Rahini; Chidambaram, Subbulakshmi.
  • Arunachalam JP; Central Inter-Disciplinary Research Facility, Sri Balaji Vidyapeeth [Deemed to be University], SBV-Mahatma Gandhi Medical College & Research Institute Campus, Pondicherry 607402, India.
  • U R A; UR Anoop Research Group, Pondicherry 605008, India.
  • Verma K; UR Anoop Research Group, Pondicherry 605008, India.
  • Rajendran R; Central Inter-Disciplinary Research Facility, Sri Balaji Vidyapeeth [Deemed to be University], SBV-Mahatma Gandhi Medical College & Research Institute Campus, Pondicherry 607402, India.
  • Chidambaram S; Department of Biochemistry and Molecular Biology, Pondicherry Central University, Puducherry 605014, India.
ACS Omega ; 6(10): 7068-7072, 2021 Mar 16.
Article in English | MEDLINE | ID: covidwho-1172544
Semantic information from SemMedBD (by NLM)
1. Neurologic Manifestations COEXISTS_WITH COVID-19
Subject
Neurologic Manifestations
Predicate
COEXISTS_WITH
Object
COVID-19
2. Proteins PART_OF 2019 novel coronavirus
Subject
Proteins
Predicate
PART_OF
Object
2019 novel coronavirus
3. Brain Stem LOCATION_OF Proteins
Subject
Brain Stem
Predicate
LOCATION_OF
Object
Proteins
4. Connective Tissue PART_OF Respiratory Mucosa
Subject
Connective Tissue
Predicate
PART_OF
Object
Respiratory Mucosa
5. Neurologic Manifestations COEXISTS_WITH COVID-19
Subject
Neurologic Manifestations
Predicate
COEXISTS_WITH
Object
COVID-19
6. Proteins PART_OF 2019 novel coronavirus
Subject
Proteins
Predicate
PART_OF
Object
2019 novel coronavirus
7. Brain Stem LOCATION_OF Proteins
Subject
Brain Stem
Predicate
LOCATION_OF
Object
Proteins
8. Connective Tissue PART_OF Respiratory Mucosa
Subject
Connective Tissue
Predicate
PART_OF
Object
Respiratory Mucosa
ABSTRACT
Neurological manifestations have been reported in COVID-19; however, the route used by SARS-CoV-2 to enter the brain is still under debate. Recent studies have focused on the olfactory route. SARS-CoV-2 viral proteins were also detected in the glossopharyngeal and vagal nerves originating from the lower brainstem and in isolated cells of the brainstem. Our proof of concept in vivo real-time imaging study of mice using an indocyanine green dye indicated that the neurovascular component of the connective tissue of the respiratory mucosa can also provide an alternate route to the brain.

Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: ACS Omega Year: 2021 Document Type: Article Affiliation country: Acsomega.1c00030

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: ACS Omega Year: 2021 Document Type: Article Affiliation country: Acsomega.1c00030