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Toward the Next-Generation COVID-19 Vaccines That Circumvent Antigenic Drift while Defusing Viral Infection.
Fernández, Ariel.
  • Fernández A; Daruma Institute for AI in Pharmaceutical Research, AF Innovation Pharma Consultancy, 4000 Pemberton Court, Winston-Salem, North Carolina 27106, United States.
ACS Pharmacol Transl Sci ; 4(2): 1018-1020, 2021 Apr 09.
Article in English | MEDLINE | ID: covidwho-1172545
ABSTRACT
The emergence of vaccine-resistant variants suggests a complicated endemic scenario in the vaccination aftermath for COVID-19. The situation prompts us to enquire whether the antigen adopted by extant vaccines, the trimeric spike (S) protein, is the optimal in the sense of inducing an immunity that leaves the virus with no evolutionary route of evasion. The patterns of glycosylation camouflage suggest that the answer is negative while also suggesting an alternative antigen that appears to be better optimized, eliciting an additional immune attack as the virus gets primed for cell penetration. This type of vaccine is expected to induce antibodies capable of defusing the virus during the priming phase while also circumventing antigenic drift.

Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines / Variants Language: English Journal: ACS Pharmacol Transl Sci Year: 2021 Document Type: Article Affiliation country: Acsptsci.1c00054

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines / Variants Language: English Journal: ACS Pharmacol Transl Sci Year: 2021 Document Type: Article Affiliation country: Acsptsci.1c00054