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Ultra-sensitive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antigen Detection for the Diagnosis of Coronavirus Disease 2019 (COVID-19) in Upper Respiratory Samples.
Wang, Hannah; Hogan, Catherine A; Verghese, Michelle; Solis, Daniel; Sibai, Mamdouh; Huang, ChunHong; Zehnder, James; Sahoo, Malaya K; Pinsky, Benjamin A.
  • Wang H; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Hogan CA; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Verghese M; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Solis D; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Sibai M; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Huang C; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Zehnder J; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Sahoo MK; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Pinsky BA; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Clin Infect Dis ; 73(12): 2326-2328, 2021 12 16.
Article in English | MEDLINE | ID: covidwho-1172645
ABSTRACT
An ultra-sensitive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid antigen assay (S-PLEX, MesoScale Diagnostics) was evaluated in 250 retrospective and 200 prospective upper respiratory specimens. In samples with cycle threshold <35, there was 95%-98% positive and 93%-96% negative percent agreement with reverse transcription-polymerase chain reaction. S-PLEX may provide a high-throughput alternative to nucleic acid-based testing for coronavirus disease 2019 (COVID-19) diagnosis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid