Whole blood stability evaluation of monoclonal antibody therapeutics using volumetric absorptive microsampling.
Bioanalysis
; 13(8): 621-629, 2021 Apr.
Article
in English
| MEDLINE | ID: covidwho-1173023
ABSTRACT
Volumetric absorptive microsampling (VAMS) is increasingly utilized for both nonclinical and clinical pharmacokinetic studies. Currently, VAMS is employed as the sampling method for the detection of antibodies for coronavirus disease 2019. Biotherapeutics whole blood stability on VAMS presents as a critical concern for the health and pharmaceutical industries. In this follow-up to our previous publication, we evaluated daclizumab and trastuzumab whole blood sample stability on VAMS. The drug recovery data we observed at room temperature for short term and -80°C for long term was very encouraging. The knowledge could help us better understand and plan important investigation timelines, especially pandemic situations where human whole blood samples from a large population are collected and in urgent need of data analysis.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Dried Blood Spot Testing
/
Antibodies, Monoclonal
Type of study:
Cohort study
/
Experimental Studies
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Bioanalysis
Year:
2021
Document Type:
Article
Affiliation country:
Bio-2021-0025
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