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Covid-19: Involvement of the nervous system. Identifying neurological predictors defining the course of the disease.
Zifko, Udo; Schmiedlechner, Theresa; Saelens, Johan; Zifko, Katharina; Wagner, Michael; Assadian, Ojan; Grisold, Wolfgang; Stingl, Harald.
  • Zifko U; Neurologische Abteilung, Evangelisches Krankenhaus, Hans-Sachs-Gasse 10-12, 1180 Wien, Austria. Electronic address: ordination@zifko.at.
  • Schmiedlechner T; Neurologische Abteilung, Evangelisches Krankenhaus, Hans-Sachs-Gasse 10-12, 1180 Wien, Austria.
  • Saelens J; Medizinische Universität Wien, Spitalgasse 23, 1090 Wien, Austria.
  • Zifko K; Medizinische Universität Wien, Spitalgasse 23, 1090 Wien, Austria.
  • Wagner M; Interne Abteilung, Landesklinikum Melk, Krankenhausstraße 11, 3390 Melk, Austria.
  • Assadian O; Ärztliche Direktion, Landesklinikum Wiener Neustadt, Corvinusring 3-5, 2700 Wiener Neustadt, Austria.
  • Grisold W; Ludwig-Boltzmann-Institute for Experimental and Clinical Traumatology, Donaueschingenstraße 13, A-1200 Wien, Austria.
  • Stingl H; Interne Abteilung, Landesklinikum Melk, Krankenhausstraße 11, 3390 Melk, Austria.
J Neurol Sci ; 425: 117438, 2021 06 15.
Article in English | MEDLINE | ID: covidwho-1174388
Semantic information from SemMedBD (by NLM)
1. Neurologic Symptoms PROCESS_OF Patients
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
Patients
2. Neurologic Symptoms PROCESS_OF inpatient
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
inpatient
3. Neurologic Symptoms PROCESS_OF Outpatients
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
Outpatients
4. COVID-19 AFFECTS inpatient
Subject
COVID-19
Predicate
AFFECTS
Object
inpatient
5. COVID-19 AFFECTS Outpatients
Subject
COVID-19
Predicate
AFFECTS
Object
Outpatients
6. Neurologic Symptoms PROCESS_OF Patients
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
Patients
7. Neurologic Symptoms PROCESS_OF inpatient
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
inpatient
8. Neurologic Symptoms PROCESS_OF Outpatients
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
Outpatients
9. COVID-19 AFFECTS inpatient
Subject
COVID-19
Predicate
AFFECTS
Object
inpatient
10. COVID-19 AFFECTS Outpatients
Subject
COVID-19
Predicate
AFFECTS
Object
Outpatients
ABSTRACT
The main objective of this study was to analyse neurological symptoms during a Covid-19 infection and determine the pattern of symptoms by comparing outpatients with inpatients. A further goal was to identify possible predictors, such as pre-existing conditions and neurological symptoms. We recorded the clinical data of 40 inpatients and 42 outpatients in this retrospective, cross sectional study. Of them, 68 patients (83%), evenly distributed between the two groups, suffered from neurological symptoms. We identified the onset of neurological symptoms and the related time ranges in 41 patients (36 outpatients and 5 inpatients). Of these, 63.4% reported neurological symptoms on the first or second day of illness. 49 patients (72%) showed combinations of at least two to a maximum of seven different neurological symptoms. A more severe course of disease was correlated with age and male sex, but age was not identified as a predictor for the occurrence of neurological symptoms. Women suffered from central and neuromuscular symptoms more often than men (p = 0,004). The most common symptoms were fatigue (54%), headache (31%), loss of taste (31%), and loss of smell (27%). Pre-existing dementia was associated with increased lethality; similarly, pre-existing stroke was associated with a more severe course of Covid-19 infection. Hallucinations and confusion were related to an increased likelihood of death. The present data demonstrate the importance of comprehensive neurological support of inpatients and outpatients affected by Covid-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Male Language: English Journal: J Neurol Sci Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Male Language: English Journal: J Neurol Sci Year: 2021 Document Type: Article