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Prognostic value of thrombin generation parameters in hospitalized COVID-19 patients.
de la Morena-Barrio, María Eugenia; Bravo-Pérez, Carlos; Miñano, Antonia; de la Morena-Barrio, Belén; Fernandez-Perez, María Piedad; Bernal, Enrique; Gómez-Verdu, José Miguel; Herranz, María Teresa; Vicente, Vicente; Corral, Javier; Lozano, María Luisa.
  • de la Morena-Barrio ME; Servicio de Hematología y Oncología Médica, Hospital General Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER, Avda. Marqués de Los Vélez, s/n, 30008, Murcia, Spain.
  • Bravo-Pérez C; Servicio de Hematología y Oncología Médica, Hospital General Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER, Avda. Marqués de Los Vélez, s/n, 30008, Murcia, Spain.
  • Miñano A; Servicio de Hematología y Oncología Médica, Hospital General Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER, Avda. Marqués de Los Vélez, s/n, 30008, Murcia, Spain.
  • de la Morena-Barrio B; Servicio de Hematología y Oncología Médica, Hospital General Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER, Avda. Marqués de Los Vélez, s/n, 30008, Murcia, Spain.
  • Fernandez-Perez MP; Servicio de Hematología y Oncología Médica, Hospital General Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER, Avda. Marqués de Los Vélez, s/n, 30008, Murcia, Spain.
  • Bernal E; Servicio de Enfermedades Infecciosas, Hospital Reina Sofía, Murcia, Spain.
  • Gómez-Verdu JM; Servicio de Medicina Interna, Hospital Universitario Morales Meseguer, Murcia, Spain.
  • Herranz MT; Servicio de Medicina Interna, Hospital Universitario Morales Meseguer, Murcia, Spain.
  • Vicente V; Servicio de Hematología y Oncología Médica, Hospital General Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER, Avda. Marqués de Los Vélez, s/n, 30008, Murcia, Spain.
  • Corral J; Servicio de Hematología y Oncología Médica, Hospital General Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER, Avda. Marqués de Los Vélez, s/n, 30008, Murcia, Spain. Javier.corral@carm.es.
  • Lozano ML; Servicio de Hematología y Oncología Médica, Hospital General Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER, Avda. Marqués de Los Vélez, s/n, 30008, Murcia, Spain.
Sci Rep ; 11(1): 7792, 2021 04 08.
Article in English | MEDLINE | ID: covidwho-1174699
ABSTRACT
SARS-CoV-2 infection increases the risk of thrombosis by different mechanisms not fully characterized. Although still debated, an increase in D-dimer has been proposed as a first-line hemostasis test associated with thromboembolic risk and unfavorable prognosis. We aim to systematically and comprehensively evaluate the association between thrombin generation parameters and the inflammatory and hypercoagulable state, as well as their prognostic value in COVID-19 patients. A total of 127 hospitalized patients with confirmed COVID-19, 24 hospitalized patients with SARS-CoV-2-negative pneumonia and 12 healthy subjects were included. Clinical characteristics, thrombin generation triggered by tissue factor with and without soluble thrombomodulin, and also by silica, as well as other biochemical parameters were assessed. Despite the frequent use of heparin, COVID-19 patients had similar thrombin generation to healthy controls. In COVID-19 patients, the thrombin generation lag-time positively correlated with markers of cell lysis (LDH), inflammation (CRP, IL-6) and coagulation (D-dimer), while the endogenous thrombin potential (ETP) inversely correlated with D-dimer and LDH, and positively correlated with fibrinogen levels. Patients with more prolonged lag-time and decreased ETP had higher peak ISTH-DIC scores, and had more severe disease (vascular events and death). The ROC curve and Kaplan Meier estimate indicated that the D-dimer/ETP ratio was associated with in-hospital mortality (HR 2.5; p = 0.006), and with the occurrence of major adverse events (composite end-point of vascular events and death) (HR 2.38; p = 0.004). The thrombin generation ETP and lag-time variables correlate with thromboinflammatory markers, and the D-dimer/ETP ratio can predict major adverse events in COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombin / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-85906-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombin / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-85906-y