[Involvement of the complement cascade in severe forms of COVID-19]. / Implication de la cascade du complément dans les formes sévères de COVID-19.
Med Sci (Paris)
; 37(4): 333-341, 2021 Apr.
Article
in French
| MEDLINE | ID: covidwho-1174712
ABSTRACT
The complement system is an essential component of the innate immune system. Its excessive activation during COVID-19 contributes to cytokine storm, disease-specific endothelial inflammation (endotheliitis) and thrombosis that comes with the disease. Targeted therapies of complement inhibition in COVID-19, in particular blocking the C5a-C5aR1 axis have to be taken into account in the establishment of potential biomarkers and development of therapeutic strategies in the most severe forms of the disease.
TITLE Implication de la cascade du complément dans les formes sévères de COVID-19. ABSTRACT Le système du complément est un composant essentiel du système immunitaire inné. Son activation excessive au cours de la COVID-19 participe à l'orage cytokinique, à l'inflammation endothéliale (endothélite) et aux thromboses qui accompagnent la maladie. Bloquer le complément, notamment l'axe C5a-C5aR1, par des thérapies spécifiques représente un espoir thérapeutique dans les formes les plus sévères de la maladie.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Complement System Proteins
/
Complement Activation
/
COVID-19
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Animals
/
Humans
Language:
French
Journal:
Med Sci (Paris)
Journal subject:
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
Medsci
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