Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination.
N Engl J Med
; 384(22): 2124-2130, 2021 06 03.
Article
in English
| MEDLINE | ID: covidwho-1174740
ABSTRACT
We report findings in five patients who presented with venous thrombosis and thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against coronavirus disease 2019 (Covid-19). The patients were health care workers who were 32 to 54 years of age. All the patients had high levels of antibodies to platelet factor 4-polyanion complexes; however, they had had no previous exposure to heparin. Because the five cases occurred in a population of more than 130,000 vaccinated persons, we propose that they represent a rare vaccine-related variant of spontaneous heparin-induced thrombocytopenia that we refer to as vaccine-induced immune thrombotic thrombocytopenia.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Autoantibodies
/
Thrombocytopenia
/
Thrombosis
/
Platelet Factor 4
/
COVID-19 Vaccines
Type of study:
Case report
/
Prognostic study
Topics:
Vaccines
/
Variants
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
N Engl J Med
Year:
2021
Document Type:
Article
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