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Drug-induced Liver Injury in a Patient With Coronavirus Disease 2019: Potential Interaction of Remdesivir With P-Glycoprotein Inhibitors.
Leegwater, Emiel; Strik, Anne; Wilms, Erik B; Bosma, Liesbeth B E; Burger, David M; Ottens, Thomas H; van Nieuwkoop, Cees.
  • Leegwater E; Department of Hospital Pharmacy, Haga Teaching Hospital, The Hague, The Netherlands.
  • Strik A; The Hague Hospital Pharmacy, The Hague, The Netherlands.
  • Wilms EB; Department of Internal Medicine, Haga Teaching Hospital, The Hague, The Netherlands.
  • Bosma LBE; Department of Hospital Pharmacy, Haga Teaching Hospital, The Hague, The Netherlands.
  • Burger DM; The Hague Hospital Pharmacy, The Hague, The Netherlands.
  • Ottens TH; Department of Hospital Pharmacy, Haga Teaching Hospital, The Hague, The Netherlands.
  • van Nieuwkoop C; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Clin Infect Dis ; 72(7): 1256-1258, 2021 04 08.
Article in English | MEDLINE | ID: covidwho-1174888
ABSTRACT
We report a case of a man with COVID-19 who developed acute hepatotoxicity related to remdesivir with probable interaction of P-glycoprotein (P-gp) inhibitors. Until further details on this interaction become available, we recommend physicians to be cautious with the prescription of P-gp inhibitors in patients receiving remdesivir therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chemical and Drug Induced Liver Injury / COVID-19 Drug Treatment Type of study: Case report Limits: Humans / Male Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chemical and Drug Induced Liver Injury / COVID-19 Drug Treatment Type of study: Case report Limits: Humans / Male Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid