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Early Differences in Cytokine Production by Severity of Coronavirus Disease 2019.
Tjan, Lidya Handayani; Furukawa, Koichi; Nagano, Tatsuya; Kiriu, Tatsunori; Nishimura, Mitsuhiro; Arii, Jun; Hino, Yasuhisa; Iwata, Sachiyo; Nishimura, Yoshihiro; Mori, Yasuko.
  • Tjan LH; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
  • Furukawa K; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
  • Nagano T; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
  • Kiriu T; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
  • Nishimura M; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
  • Arii J; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
  • Hino Y; Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
  • Iwata S; Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
  • Nishimura Y; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
  • Mori Y; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
J Infect Dis ; 223(7): 1145-1149, 2021 04 08.
Article in English | MEDLINE | ID: covidwho-1174909
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Symptom mild PROCESS_OF Patients
Subject
Symptom mild
Predicate
PROCESS_OF
Object
Patients
3. Epidermal cGVHD Score 2 PROCESS_OF Patients
Subject
Epidermal cGVHD Score 2
Predicate
PROCESS_OF
Object
Patients
4. cytokine ASSOCIATED_WITH COVID-19
Subject
cytokine
Predicate
ASSOCIATED_WITH
Object
COVID-19
5. interleukin-12 TREATS Epidermal cGVHD Score 2
Subject
interleukin-12
Predicate
TREATS
Object
Epidermal cGVHD Score 2
6. Serum LOCATION_OF cytokine
Subject
Serum
Predicate
LOCATION_OF
Object
cytokine
7. Borg Category-Ratio 10 Perceived Exertion Score 5 PROCESS_OF Patients
Subject
Borg Category-Ratio 10 Perceived Exertion Score 5
Predicate
PROCESS_OF
Object
Patients
8. cytokine PART_OF Patients
Subject
cytokine
Predicate
PART_OF
Object
Patients
9. Patients LOCATION_OF cytokine
Subject
Patients
Predicate
LOCATION_OF
Object
cytokine
10. Interleukin-2 TREATS Patients
Subject
Interleukin-2
Predicate
TREATS
Object
Patients
11. interleukin-12 TREATS Patients
Subject
interleukin-12
Predicate
TREATS
Object
Patients
12. cytokine ASSOCIATED_WITH Asymptomatic Infections
Subject
cytokine
Predicate
ASSOCIATED_WITH
Object
Asymptomatic Infections
13. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
14. Symptom mild PROCESS_OF Patients
Subject
Symptom mild
Predicate
PROCESS_OF
Object
Patients
15. Epidermal cGVHD Score 2 PROCESS_OF Patients
Subject
Epidermal cGVHD Score 2
Predicate
PROCESS_OF
Object
Patients
16. cytokine ASSOCIATED_WITH COVID-19
Subject
cytokine
Predicate
ASSOCIATED_WITH
Object
COVID-19
17. interleukin-12 TREATS Epidermal cGVHD Score 2
Subject
interleukin-12
Predicate
TREATS
Object
Epidermal cGVHD Score 2
18. Serum LOCATION_OF cytokine
Subject
Serum
Predicate
LOCATION_OF
Object
cytokine
19. Borg Category-Ratio 10 Perceived Exertion Score 5 PROCESS_OF Patients
Subject
Borg Category-Ratio 10 Perceived Exertion Score 5
Predicate
PROCESS_OF
Object
Patients
20. cytokine PART_OF Patients
Subject
cytokine
Predicate
PART_OF
Object
Patients
21. Patients LOCATION_OF cytokine
Subject
Patients
Predicate
LOCATION_OF
Object
cytokine
22. Interleukin-2 TREATS Patients
Subject
Interleukin-2
Predicate
TREATS
Object
Patients
23. interleukin-12 TREATS Patients
Subject
interleukin-12
Predicate
TREATS
Object
Patients
24. cytokine ASSOCIATED_WITH Asymptomatic Infections
Subject
cytokine
Predicate
ASSOCIATED_WITH
Object
Asymptomatic Infections
ABSTRACT
Most patients with coronavirus disease 2019 (COVID-19) experience asymptomatic disease or mild symptoms, but some have critical symptoms requiring intensive care. It is important to determine how patients with asymptomatic or mild COVID-19 react to severe acute respiratory syndrome coronavirus 2 infection and suppress virus spread. Innate immunity is important for evasion from the first virus attack, and it may play an important role in the pathogenesis in these patients. We measured serum cytokine levels in 95 patients with COVID-19 during the infection's acute phase and report that significantly higher interleukin 12 and 2 levels were induced in patients with asymptomatic or mild disease than in those with moderate or severe disease, indicating the key roles of these cytokines in the pathogenesis of asymptomatic or mild COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukin-2 / Interleukin-12 / SARS-CoV-2 / COVID-19 / Immunity, Innate Type of study: Diagnostic study / Observational study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukin-2 / Interleukin-12 / SARS-CoV-2 / COVID-19 / Immunity, Innate Type of study: Diagnostic study / Observational study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis