Your browser doesn't support javascript.
Cutaneous Vasculopathy in a COVID-19 Critically Ill Patient: A Histologic, Immunohistochemical, and Electron Microscopy Study.
Kyriakoudi, Anna; Pontikis, Konstantinos; Tsaraklis, Athanasios; Soura, Efthymia; Vourlakou, Christine; Kossyvakis, Athanasios; Potamianou, Efstathia; Kaniaris, Evangelos; Ioannidou, Iliana; Mentis, Andreas; Kloukina, Ismini; Daganou, Maria; Koutsoukou, Antonia.
  • Kyriakoudi A; ICU, 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens Medical School, "Sotiria" Hospital, Athens, Greece.
  • Pontikis K; ICU, 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens Medical School, "Sotiria" Hospital, Athens, Greece.
  • Tsaraklis A; Dermatology Department, "Sotiria" Hospital, Athens, Greece.
  • Soura E; 1st Department of Dermatology-Venereology, National and Kapodistrian University of Athens, Andreas Sygros Hospital, Athens, Greece.
  • Vourlakou C; Pathology Department, Evangelismos General Hospital, Athens, Greece.
  • Kossyvakis A; Public Health Laboratories, Hellenic Pasteur Institute, Athens, Greece.
  • Potamianou E; ICU, 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens Medical School, "Sotiria" Hospital, Athens, Greece.
  • Kaniaris E; ICU, 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens Medical School, "Sotiria" Hospital, Athens, Greece.
  • Ioannidou I; ICU, 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens Medical School, "Sotiria" Hospital, Athens, Greece.
  • Mentis A; Public Health Laboratories, Hellenic Pasteur Institute, Athens, Greece.
  • Kloukina I; Center of Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece.
  • Daganou M; ICU, 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens Medical School, "Sotiria" Hospital, Athens, Greece.
  • Koutsoukou A; ICU, 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens Medical School, "Sotiria" Hospital, Athens, Greece.
Case Rep Crit Care ; 2021: 6644853, 2021.
Article in English | MEDLINE | ID: covidwho-1175216
ABSTRACT
We describe a critically ill, SARS-CoV-2 positive patient with respiratory failure and thrombotic/livedoid skin lesions, appearing during the course of the disease. The biopsy of the lesions revealed an occlusive, pauci-inflammatory vasculopathy of the cutaneous small vessels characterized by complement and fibrinogen deposition on vascular walls, pointing to a thrombotic vasculopathy. Transmission electron microscopy of the affected skin failed to reveal any viral inclusions. Clinical evaluation and laboratory findings ruled out systemic coagulopathies and disseminated intravascular coagulation, drug-induced skin reaction, and common viral rashes. Our hypothesis is that the, herein evidenced, microvascular occlusive injury might constitute a significant pathologic mechanism in COVID-19, being a common denominator between cutaneous and pulmonary manifestations.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Experimental Studies / Prognostic study Language: English Journal: Case Rep Crit Care Year: 2021 Document Type: Article Affiliation country: 2021

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Experimental Studies / Prognostic study Language: English Journal: Case Rep Crit Care Year: 2021 Document Type: Article Affiliation country: 2021