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Seroprevalence of COVID-19 infection in a rural district of South India: A population-based seroepidemiological study.
Inbaraj, Leeberk Raja; George, Carolin Elizabeth; Chandrasingh, Sindhulina.
  • Inbaraj LR; Division of Community Health and Family Medicine, Bangalore Baptist Hospital, Bangalore, Karnataka, India.
  • George CE; Division of Community Health and Family Medicine, Bangalore Baptist Hospital, Bangalore, Karnataka, India.
  • Chandrasingh S; Department of Microbiology, Bangalore Baptist Hospital, Bangalore, Karnataka, India.
PLoS One ; 16(3): e0249247, 2021.
Article in English | MEDLINE | ID: covidwho-1175427
Semantic information from SemMedBD (by NLM)
1. immunoglobulin G TREATS 2019 novel coronavirus
Subject
immunoglobulin G
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TREATS
Object
2019 novel coronavirus
2. Diabetes PROCESS_OF Participant
Subject
Diabetes
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PROCESS_OF
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Participant
3. Hypertensive disease PROCESS_OF Participant
Subject
Hypertensive disease
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PROCESS_OF
Object
Participant
4. Infected PROCESS_OF Persons
Subject
Infected
Predicate
PROCESS_OF
Object
Persons
5. COVID-19 AFFECTS Rural Population
Subject
COVID-19
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AFFECTS
Object
Rural Population
6. Stress PROCESS_OF Social Networks
Subject
Stress
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PROCESS_OF
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Social Networks
7. immunoglobulin G TREATS 2019 novel coronavirus
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immunoglobulin G
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TREATS
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2019 novel coronavirus
8. Diabetes PROCESS_OF Participant
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Diabetes
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PROCESS_OF
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Participant
9. Hypertensive disease PROCESS_OF Participant
Subject
Hypertensive disease
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PROCESS_OF
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Participant
10. Infected PROCESS_OF Persons
Subject
Infected
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PROCESS_OF
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Persons
11. COVID-19 AFFECTS Rural Population
Subject
COVID-19
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AFFECTS
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Rural Population
12. Stress PROCESS_OF Social Networks
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Stress
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PROCESS_OF
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ABSTRACT

OBJECTIVES:

We aimed to estimate the seroprevalence of COVID-19 in a rural district of South India, six months after the index case.

METHODOLOGY:

We conducted a cross-sectional study of 509 adults aged more than 18 years. From all the four subdistricts, two grampanchayats (administrative cluster of 5-8 villages) were randomly selected followed by one village through convenience. The participants were invited for the study to the community-based study kiosk set up in all the eight villages through village health committees. We collected socio-demographic characteristics and symptoms using a mobile application-based questionnaire, and we tested samples for the presence of IgG antibodies for SARS CoV-2 using an electro chemiluminescent immunoassay. We calculated age-gender adjusted and test performance adjusted seroprevalence.

RESULTS:

The age-and gender-adjusted seroprevalence was 8.5% (95% CI 6.9%- 10.8%). The unadjusted seroprevalence among participants with hypertension and diabetes was 16.3% (95% CI9.2-25.8) and 10.7% (95% CI 5.5-18.3) respectively. When we adjusted for the test performance, the seroprevalence was 6.1% (95% CI 4.02-8.17). The study estimated 7 (95% CI 14.5-19) undetected infected individuals for every RT-PCR confirmed case. Infection Fatality Rate (IFR) was calculated as 12.38 per 10000 infections as on 22 October 2020. History of self-reported symptoms and education were significantly associated with positive status (p < 0.05).

CONCLUSION:

A significant proportion of the rural population in a district of south India remains susceptible to COVID-19. A higher proportion of susceptible, relatively higher IFR and a poor tertiary healthcare network stress the importance of sustaining the public health measures and promoting early access to the vaccine are crucial to preserving the health of this population. Low population density, good housing, adequate ventilation, limited urbanisation combined with public, private and local health leadership are critical components of curbing future respiratory pandemics.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Rural Population / COVID-19 Type of study: Randomized controlled trials / Risk factors Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0249247

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rural Population / COVID-19 Type of study: Randomized controlled trials / Risk factors Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0249247