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Sinonasal manifestations and dynamic profile of RT-PCR results for SARS-CoV-2 in COVID-19 patients.
Jia, Xiaoqing; Shao, Shan; Ren, Hong; Xu, Yuan; Zhao, Jinming; Zhao, Yan; Wang, Yue; Bao, Shiping; Yan, Junping; Wang, Xiangdong; Zhang, Luo.
  • Jia X; Department of Respiration, Third Hospital of Baotou City, Baotou, China.
  • Shao S; Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otorhinolaryngology-Head & Neck Surgery Ministry of Education, Capital Medical University, Beijing, China; Department of Otolaryngology Head and Neck Surgery, Beijing Youan Hospital, Capital Medi
  • Ren H; Department of Infection, Third Hospital of Baotou City, Baotou, China.
  • Xu Y; Departments of Oncology, Community Health Sciences, and Surgery, Cumming School of Medicine, and The Center for Health Informatics, University of Calgary, Calgary, Canada.
  • Zhao J; Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otorhinolaryngology-Head & Neck Surgery Ministry of Education, Capital Medical University, Beijing, China.
  • Zhao Y; Beijing Institute of Otolaryngology, Beijing Key Laboratory of Nasal Diseases, Beijing, China.
  • Wang Y; Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otorhinolaryngology-Head & Neck Surgery Ministry of Education, Capital Medical University, Beijing, China.
  • Bao S; Department of Otolaryngology Head and Neck Surgery, Beijing Youan Hospital, Capital Medical University, Beijing, China.
  • Yan J; Department of Respiration, Third Hospital of Baotou City, Baotou, China.
  • Wang X; Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otorhinolaryngology-Head & Neck Surgery Ministry of Education, Capital Medical University, Beijing, China; Beijing Institute of Otolaryngology, Beijing Key Laboratory of Nasal Diseases, Beijing,
  • Zhang L; Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otorhinolaryngology-Head & Neck Surgery Ministry of Education, Capital Medical University, Beijing, China; Beijing Institute of Otolaryngology, Beijing Key Laboratory of Nasal Diseases, Beijing,
Ann Palliat Med ; 10(4): 4174-4183, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-1175845
ABSTRACT

BACKGROUND:

Sinonasal symptoms were usually reported to appear initially, yielding the symptoms important for the early detection of coronavirus disease 2019 (COVID-19). This study was conducted retrospectively to investigate the detailed sinonasal manifestations and dynamic profile of real-time reverse transcription polymerase chain reaction (RT-PCR) results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in COVID-19 patients longitudinally.

METHODS:

This retrospective study included 11 consecutive patients. The prevalence, timing and severity of sinonasal manifestations were analyzed. Oropharyngeal, nasal, sputum and stool specimens were collected to detect RT-PCR for SARS-CoV-2 over COVID-19 period.

RESULTS:

Among the 11 patients, 6 (54.5%) were female, and the median age was 51 (IQR, 36-62) years. Seven patients (63.6%) experienced sinonasal symptoms, with 6 (54.5%) exhibiting sinonasal symptoms on the onset day. Seven patients (63.6%) demonstrated nasal obstruction, 5 (45.5%) had rhinorrhea, and 4 (36.4%) exhibited olfactory dysfunction. All six patients with sinonasal symptoms on the onset day had non-severe infections. Most patients (85.7%) with sinonasal symptoms had non-severe infections. Sinonasal symptoms commonly appeared early. The positive RT-PCR rate for SARS-CoV-2 in various specimens was highest in the first week (73.3%), then gradually decreased over the disease course, but 3 patients (27.3%) had experienced a long-lasting fluctuated positive RT-PCR results since 29 days of illness in both groups, especially for two patients with airway comorbidities.

CONCLUSIONS:

Sinonasal symptoms were more prevalent in patients with mild or moderate COVID-19 and usually appeared early. In addition, regular nucleic acid testing for SARS-CoV-2 should be considered for COVID-19 patients with certain airway comorbidities.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male / Middle aged Language: English Journal: Ann Palliat Med Year: 2021 Document Type: Article Affiliation country: Apm-20-2493

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male / Middle aged Language: English Journal: Ann Palliat Med Year: 2021 Document Type: Article Affiliation country: Apm-20-2493